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东南大学学报(医学版) 2006,Jan;25(1):73O75 () JSoutheastUnivMedSciEdi·73· matrixmetalloproteinase22activityinratmesangialcellsvia [5]VUTH,WERBZ.Matrixmetalloproteinases:effectorsofde2 transforminggrowthfactor2beta[J].ExpNephrol,2001,9:249O257. velopmentandnormalphysiology[J].GenesDev,2000,14: [13]McLENNANSV,MARTELLSKY,YUEDK.Highglucose 2123O2133. concentrationinhibitstheexpressionofmembranetypemetal2 [6]BODEW,FERNANDEZOCATALANC,GRAMSF,etal.In2 loproteinasebymesangialcells:possibleroleinmesangium sightsintoMMPOTIMPinteractions[J].AnnNYAcadSci, accumulation[J].Diabetologia,2000,43:642O648. 1999,878:73O91. [14]LUPIAE,ELLIOTSJ,LENZO,etal.IGFO1decreasescolla2 [7]WUK,SETTYS,MAUERSM,etal.Alteredkidneymatrix gendegradationindiabeticNODmesangialcells:implications geneexpressioninearlystagesofexperimentaldiabetes[J]. fordiabeticnephropathy[J].Diabetes,1999,48:1638O1644. ActaAnatBasel,1997,158:155O165. [15]McLENNANSV,MARTELLSKY,YUEDK.Effectsof [8]EBIHARALJ,NAKAMURAT,SHIMADAN,etal.Increased mesangiumglycationonmatrixmetalloproteinaseactivities: plasmametalloproteinase9concentrationsprecededevelopment possibleroleindiabeticnephropathy[J].Diabetes,2002,51: ofmicroalbuminuriainnoninsulindependentdiabetesmellitus 2612O2618. [J].AmJKidenyDis,1998,32:544O550. [16]于晓燕,李才,何泽,等.糖基化终末产物对大鼠肾皮质基 [9]TASHIROK,KOYANAGII,OHARAI,etal.Levelsofurinary 质金属蛋白酶2活性和表达的影响[J].中华内分泌代谢 matrixmetalloproteinase29(MMPO9)andrenalinjuriesinpa2 杂志,2003,19:402O405. tientswithtype2diabeticnephropathy[J].JClinLabAnal, [17]BARICOSWH,CORTEZSL,DEBOISBLANCM,etal.Trans2 2004,18(3):206O210. forminggrowthfactor2betaisapotentinhibitorofextracellular [10]GIUSEPPED,MARIAAA,DIEGOG,etal.MatrixMetallo2 matrixdegradationculturedhumanmesangialcells[J].JAm proteinase2maybeamarkerofmicroangiopathyinchildren SocNephrol,1999,10:795. andadolescentswithtype1diabetes[J].DiabetesCare, [18]McLENNANSV,WANGXY,MORENOV,etal.Connec2 2004,27:273O274. tivetissuegrowthfactormediateshighglucoseeffectsonma2 [11]McLENNANSV,KELLYDJ,COXAJ,etal.Decreasedma2 t