磷酸奥司他韦治疗小儿流行性感冒的临床效果.pdf

临床医学临床医学研究与实践2021年4月第6卷第12期磷酸奥司他韦治疗小儿流行性感冒的临床效果康永桂1，刘维娜2*（1.咸阳市妇幼保健院，陕西咸阳，712046；2.宝鸡市第三人民医院，陕西宝鸡，721004）摘要：目的观察磷酸奥司他韦治疗小儿流行性感冒（流感）的临床效果。方法选取2017年11月至2019年3月我院收治的300例流感患儿作为研究对象，按照随机数字表法将其分为对照组和观察组，各150例。对照组给予抗感颗粒治疗，观察组给予磷酸奥司他韦治疗。比较两组患儿的治疗效果。结果观察组的治疗总有效率明显高于对照组（P约0.05）。治疗后，两组发热、咽喉痛、咳嗽、鼻塞流涕评分均较治疗前降低，且观察组低于对照组（P约0.05）。治疗后，两组的NEU%、WBC均较治疗前降低，且观察组低于对照组（P约0.05）。治疗后，两组的CRP、TNF-琢水平均较治疗前降低，CD3+、CD4+均较治疗前升高，且观察组优于对照组（P约0.05）。观察组的不良反应总发生率低于对照组（P约0.05）。结论磷酸奥司他韦治疗小儿流感效果显著，可有效缓解临床症状，改善外周血象及免疫功能，降低炎症因子水平，且用药不良反应少。关键词：磷酸奥司他韦；小儿；流感中图分类号：R97文献标志码：A文章编号：2096-1413(2021)12-0092-03ClinicaleffectofoseltamivirphosphateinthetreatmentofchildrenwithinfluenzaKANGYonggui1,LIUWeina2*(1.XianyangMaternalandChildHealthHospital,Xianyang712046;2.BaojiThirdPeople'sHospital,Baoji721004,China)ABSTRACT:ObjectiveToobservetheclinicaleffectofoseltamivirphosphateinthetreatmentofchildrenwithinfluenza.MethodsAtotalof300childrenwithinfluenzaadmittedinourhospitalfromNovember2017toMarch2019wereselectedastheresearchobjectsanddividedintocontrolgroupandobservationgroupaccordingtorandomnumbertablemethod,with150casesineachgroup.Thecontrolgroupwastreatedwithkanggangranule,andtheobservationgroupwastreatedwithoseltamivirphosphate.Thetherapeuticeffectsofthetwogroupswerecompared.ResultsThetotaleffectiverateoftreatmentintheobservationgroupwassignificantlyhigherthanthatinthecontrolgroup(P<0.05).Aftertreatment,thescoresoffever,sorethroat,cough,nasalcongestionandrunnynoseinthetwogroupswerelowerthanthosebeforetreatment,andthoseintheobservationgroupwerelowerthanthecontrolgroup(P<0.05).Aftertreatment,NEU%andWBCinthetwogroupswerelowerthanthosebeforetreatment,andthoseintheobservationgroupwerelowerthanthecontrolgroup(P<0.05).Aftertreatment,thelevelsofCRPandTNF-琢inthetwogroupswerelowerthanthosebeforetreatment,whileCD3+andCD4+werehigherthanthosebeforetreatment,andthoseintheobservationgroupwerebetterthanthecontrolgroup(P<0.05).Thetotalincidenceofadversereactionsintheobservationgroupwaslowerthanthatinthecontrolgroup(P<0.05).ConclusionOs