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【精编医学资料】博士生课程5(1)-细胞因子.pptx

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8-30KDCK-CKRsJustashormonesserveasmessengeroftheendocrinesystemsocytokineseverasmessengersoftheimmunesystem.Unlikeendocrinehormonesthoughwhichexerttheireffectsoverlargedistancescytokinesgeneralactlocally.CytokinescanexertdifferentactionsPropertiesofcytokinesBiologicaleffectsofthecytokinesCytokinesduringhematopoiesisinterleukinIL〔白细胞介素〕colonystimulatingfactorCSF〔集落刺激因子〕interferonIFN〔干扰素〕tumornecrosisfactorTNF〔肿瘤坏死因子〕ChemokineCK〔趋化因子〕growthfactorGF〔生长因子〕CytokinesofinnateimmunesystemInterleukinInterleukinsaresecretedbysomeleukocytesandactuponotherleukocytesIL-1~IL-35havebeenidentified.Interleukin-1IL-1ThereleaseofTNF-abymacrophagesinduceslocalprotectiveeffectsbutTNF-acanhavedamagingeffectswhenreleasedsystemically(septicshock).IL-12producedbymacrophagesanddendriticcellsisakeycytokinetofightintracellularmicrobes(bacteriaandviruses)IL-12inducesIFN-γanactivatorofmacrophages(killingofphagocytosedmicrobes)andTh1celldifferentiationIL-12alsoincreasescytotoxicactivityofCD8andNKcellsThecytokinesthatresistviralinfectionandinterfereviralreplicationincludingIFNIFNIFNεIFNωIFNκ(typeI);IFN(typeII)IntegrativesignalingofcytokinesduringinnateimmuneresponsesCytokinesofadaptiveimmunesystemIL-4inducesIsotypeswitchingagainstextracellularpathogenssuchashelminthsandathropodesPleiotropicactivitiesofIFN-γAnti-inflammatorycytokinesAdditionalkeycytokines是一类可介导不同类型细胞生长和分化的细胞因子。根据其功能和作用的靶细胞不同分别命名为：表皮生长因子〔epidermalgrowthfactorEGF)血管内皮生长因子〔vascularendothelialgrowthfactorVEGF)成纤维细胞生长因子〔fibroblastgrowthfactorFGF)神经生长因子(nervegrowthfactorNGF)血小板衍生的生长因子〔plateletderivedgrowthfactorPDGF)肝细胞生长因子〔hepaticgrowthfactorHGF)VEGFReceptorSignalingTH1andTH2subsetssecretedifferentcytokinesTH1andTH2subsetsregulateeachotherCD4+TcellsisolationanddifferentiationSpleensweremechanical