预览加载中，请您耐心等待几秒...

最新精编医学专题—博士生课程5(1)-细胞因子.ppt

预览
1/10
2/10
3/10
4/10
5/10
6/10
7/10
8/10
9/10
10/10

亲，该文档总共89页，到这已经超出免费预览范围，如果喜欢就直接下载吧～

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

8-30KDCK-CKRsJustashormonesserveasmessengeroftheendocrinesystemsocytokineseverasmessengersoftheimmunesystem.Unlikeendocrinehormonesthoughwhichexerttheireffectsoverlargedistancescytokinesgeneralactlocally.CytokinescanexertdifferentactionsPropertiesofcytokinesBiologicaleffectsofthecytokinesCytokinesduringhematopoiesisinterleukinIL（白细胞介素）colonystimulatingfactorCSF（集落刺激因子(yīnzǐ)）interferonIFN（干扰素）tumornecrosisfactorTNF（肿瘤坏死因子）ChemokineCK（趋化因子）growthfactorGF（生长因子）第九页共八十九页。CytokinesofinnateimmunesystemInterleukinInterleukinsaresecretedbysomeleukocytesandactuponotherleukocytesIL-1~IL-35havebeenidentified.第十二页共八十九页。Interleukin-1IL-1ThereleaseofTNF-abymacrophagesinduceslocalprotectiveeffectsbutTNF-acanhavedamagingeffectswhenreleasedsystemically(septicshock).第十七页共八十九页。第十八页共八十九页。IL-12producedbymacrophagesanddendriticcellsisakeycytokinetofightintracellularmicrobes(bacteriaandviruses)IL-12inducesIFN-γanactivatorofmacrophages(killingofphagocytosedmicrobes)andTh1celldifferentiationIL-12alsoincreasescytotoxicactivityofCD8andNKcellsThecytokinesthatresistviralinfectionandinterfereviralreplicationincludingIFNIFNIFNεIFNωIFNκ(typeI);IFN(typeII)IntegrativesignalingofcytokinesduringinnateimmuneresponsesCytokinesofadaptiveimmunesystemIL-4inducesIsotypeswitchingagainstextracellularpathogenssuchashelminthsandathropodesPleiotropicactivitiesofIFN-γAnti-inflammatorycytokinesAdditionalkeycytokines是一类可介导不同类型细胞生长和分化的细胞因子。根据其功能和作用(zuòyòng)的靶细胞不同分别命名为：表皮生长因子（epidermalgrowthfactorEGF)血管内皮生长因子（vascularendothelialgrowthfactorVEGF)成纤维细胞生长因子（fibroblastgrowthfactorFGF)神经生长因子(nervegrowthfactorNGF)血小板衍生的生长因子（plateletderivedgrowthfactorPDGF)肝细胞生长因子（hepaticgrowthfactorHGF)VEGFReceptorSignalingTH1andTH2subsetssecretedifferentcytokinesTH1andTH2subsetsregulateeachotherCD4+Tcel