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甲状腺激素(jīsù)和抗甲状腺药ThyroidhormonesandantithyroiddrugsSummaryThyroidhormonesNecessarytomaintainnormalmetabolismgrowthanddevelopment.HypothyroidismCauseCretinismifithappensinembryoorneonatalperiod.Causemyxedemaifithappensinadultswhenthethyroidhormonecouldbeusedinreplacementtherapy.HyperthyroidismAsyndromcharacterizedbythyroidoversecretionandmetabolicdisordercausedbymultiplereasons.Itcanbetreatedwithradioactiveiodine(131I)irradationantithyroiddrugsandoperation.Thyroidhormones抗甲状腺药硫脲类ThyroidhormonesareiodicaminoacidsActivecomponentsThyroxineT4TriiodothyreninumnatricumT3Chemicalconstitution甲状腺激素(jīsù)的化学结构PhysiologicaldispositionofthyroidhormonesSynthesisstorageandregulationofthyroidhormonesStepsofthyroidhormonessynthesisreleaseandregulation(Ⅰ)Condensationandstorage:InthethyroidglobulinmoleculetwoDTTsarecondensedtoT4oneDTTandoneMITarecondensedtoT3whichareallstoredinglandalveoluscolloid.Disintegrationandrelease:T3andT4arereleasedintobloodafterhydrolyzedbyproteases.AtthesametimesomeofthemcanbeturnedbacktotyrosineandI-bydeiodinaseincellsandreused.Regulation:Bythepositiveandnegativefeedbackregulationofhypothalamus-anteriorlobe-thyroidaxis.HypothalamussecretsTRHanteriorlobesecretsTSHandthyroidsynthesizeT3T4.SynthesisstorageandreleaseofthyroidhormoneThyroidhormonesMechanismofaction(figure)ItisbelievednowthatthethermogenicactionofT3andT4isduetotheincreaseofsodiumpumpsactivityonthecellmembrane.Na+K+—ATPaseactivityATPutilizationADPconcentrationmitochondriarespirationoxideconsumptionandheatproductionPhysiologicalandpharmacologicalactionsThyroidclinicalapplicationAntithyroidDrugs硫脲类ThioureaPharmacologicalactionsInhibitperoxydaseinadenocyteswhichresultsintheinhibitedoxydationofI-toI0.Then