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对羟基苯甲酸乙酯和对羟基苯甲酸丙酯稳定性的研究.docx

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对羟基苯甲酸乙酯和对羟基苯甲酸丙酯稳定性的研究 Title:StabilityStudiesonEthylp-HydroxybenzoateandPropylp-Hydroxybenzoate Abstract: Para-hydroxybenzoicacidesters,suchasethylp-hydroxybenzoate(ethylparaben)andpropylp-hydroxybenzoate(propylparaben),arewidelyusedaspreservativesinpersonalcareproducts,cosmetics,andpharmaceuticalsduetotheirantimicrobialandantifungalproperties.However,concernshavebeenraisedregardingthestabilityoftheseestersundervariousconditions.Thispaperexploresthestabilityofethylparabenandpropylparaben,focusingonfactorsthatcaninfluencetheirdegradation,includingpH,temperature,lightexposure,andthepresenceofdifferentsolvents.Theresultsofthestabilitystudiesprovidevaluableinsightsintotheconditionsthatcanimpactthestabilityofthesecompoundsandaidindeterminingappropriatestorageandformulationtechniques. Introduction: Para-hydroxybenzoicacidestershavegainedsignificantattentioninrecentyearsduetotheirwiderangeofapplicationsaspreservatives.Ethylparabenandpropylparabenaretwocommonlyusedestersintheindustry.Despitetheirwidespreaduse,concernshavebeenraisedregardingtheirstability,particularlyundervaryingenvironmentalconditions.Understandingthefactorsthatinfluencetheirstabilityiscrucialforensuringtheefficacyandsafetyofproductscontainingthesecompounds. Methods: Thestabilitystudieswereconductedbysubjectingethylparabenandpropylparabentovariousconditions.DifferentpHlevelsrangingfromacidictoalkalinewereemployed,andthesampleswerestoredatdifferenttemperatures.Additionally,theimpactoflightexposureandthepresenceofvarioussolventswereinvestigated.Thestabilityoftheesterswasmonitoredoveraspecificperiodusinganalyticaltechniques,suchashigh-performanceliquidchromatography(HPLC)andspectroscopicanalysis. ResultsandDiscussion: ThestabilitystudiesrevealedthatbothethylparabenandpropylparabenarerelativelystableunderneutralpHconditions.However,theywerefoundtodegrademorerapidlyunderalkalineconditions.ThissuggeststhatthepHoftheformulationorproductplaysacrucialroleindeterminingthestabilityoftheseesters.Temperaturewasalsofoun