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手性咪唑氨基醇的合成及其在铜催化不对称Henry反应中的应用（英文）.docx

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手性咪唑氨基醇的合成及其在铜催化不对称Henry反应中的应用（英文） Title:SynthesisofChiralImidazoleAminoAlcoholsandTheirApplicationinCopper-CatalyzedAsymmetricHenryReaction Abstract: Chiralimidazoleaminoalcoholshaveplayedasignificantroleasversatileandefficientchiralligandsinvariousasymmetriccatalyticreactions.Inthispaper,weprovideacomprehensivereviewonthesynthesisofchiralimidazoleaminoalcoholsandtheirapplicationincopper-catalyzedasymmetricHenryreaction.TheHenryreaction,alsoknownasthenitro-aldolreaction,isapowerfultoolfortheconstructionofchiralβ-nitroalcoholproducts.The1,2-additionofnitroalkanetoaldehydesorketonesoccursundermildreactionconditions,providingaccesstovariousopticallyactivecompounds. Introduction: Chiralimidazoleaminoalcoholshavegainedsignificantattentionduetotheirimportantrolesasversatileligandsinasymmetriccatalysis.Theypossessauniquecombinationofaminesandalcohols,whichenablesthemtoformcoordinationcomplexeswithmetalcatalysts.Thesecomplexesexhibithighcatalyticactivityandselectivity,makingchiralimidazoleaminoalcoholsexcellentcandidatesforvariousasymmetrictransformations. SynthesisofChiralImidazoleAminoAlcohols: 1.EnantioselectiveSynthesis: Theenantioselectivesynthesisofchiralimidazoleaminoalcoholscanbeachievedthroughvariousmethodologies.Onecommonlyemployedstrategyinvolvesthereactionofimidazolewithchiralaminoalcoholsorchiralamines.Thisreactioncanbeconductedundermildconditions,andtheresultantchiralimidazoleaminoalcoholscanbeobtainedingoodtoexcellentyieldswithhighenantioselectivities. 2.Resolution: Resolutionmethodsarealsowidelyusedforthesynthesisofchiralimidazoleaminoalcohols.Thesemethodsrelyontheseparationofenantiomersbyutilizingchiralresolvingagentsortechniques,suchaschiralchromatographyorcrystallization.Afterresolution,theenantiomericallypurechiralimidazoleaminoalcoholscanbeobtainedforfurtherapplications. ApplicationsinCopper-CatalyzedAsymmetricHenryReaction: Thecopper-catalyzedasymmetricHenryreactionprovidesastraightforwardapproachforthesynthesisofchiralβ-nitroalcoholcompounds.Chiralim