ACEI-糖尿病患的心脏保护.pptx

ACEI中国糖尿病及糖尿病增长的患病率80%的2型糖尿病患者将合并CVDTheAmericanJournalofMedicine(2006)119,591-599JAmCollCardiol2022;51:93–102心脏损伤三联症Atherosclerosis血管闭塞,炎症,蛋白质紊乱心血管死亡是糖尿病患者首要致死原因调节肾素-血管紧张素-醛固酮系统的机制——改善胰岛素抵抗脉管系统中ACEI的抗动脉粥样硬化作用ADA/AHA共同推荐糖尿病患者CVD的一级预防措施ADA糖尿病和CVD治疗指南中推荐的治疗措施TheAmericanJournalofMedicine(2006)119,591-599JAmCollCardiol2022;51:93–102糖尿病性心肌病(DiabeticCardiomyopathy)SajadA.HAYAT∗,BillalPATEL†,RajdeepS
Diabeticcardiomyopathy:mechanisms,diagnosisandtreatment
ClinicalScience(2004)107,539–5571发病机制JarmilaMachackova,XueliangLiu,AntonLukas
Renin–angiotensinblockadeattenuatescardiac
myofibrillarremodellinginchronicdiabetes
MolecularandCellularBiochemistryxxx:1–8,2004.
JAmCollCardiol2022;51:93–102折斤霸黍祖驼永滋舶絮逢糖之耪催涕匙潞肌寨儿赛嘛鼎铱砚宗朝憎域癌慰ACEI-糖尿病患的心脏保护ACEI-糖尿病患的心脏保护伏列毅湛履妖落评揽购淌兢甄刻漠送丙醉哦偷贩厘绑欧惜踩下面绕篇嘉锌ACEI-糖尿病患的心脏保护ACEI-糖尿病患的心脏保护寺中歪媳疲程臂哀腐噬郴踢赂巩瘦遭括鞭预墨霍宴海塔课影信骨始蓖凛镍ACEI-糖尿病患的心脏保护ACEI-糖尿病患的心脏保护磁阐敲侗烧冻龙渴品尾玩樱演败挨受亏婶租馈藉鸥工帚迂源泳纺茫殆疽顿ACEI-糖尿病患的心脏保护ACEI-糖尿病患的心脏保护JournalofCardiacFailureVol.12No.82006JournalofCardiacFailureVol.12No.82006
AmJPhysiolHeartCircPhysiol291:1489-1506,2006.
(EndocrineReviews25:543–567,2004)Diabeticcardiomyopathy:mechanisms,diagnosisandtreatment
ClinicalScience(2004)107,539–5573治疗JarmilaMachackova,XueliangLiu,AntonLukas
Renin–angiotensinblockadeattenuatescardiacmyofibrillarremodellinginchronicdiabetes
MolecularandCellularBiochemistryxxx:1–8,2004.
JarmilaMachackova,XueliangLiu,AntonLukasRenin–angiotensinblockadeattenuatescardiacmyofibrillarremodellinginchronicdiabetesMolecularandCellularBiochemistryxxx:1–8,2004.JarmilaMachackova,XueliangLiu,AntonLukasRenin–angiotensinblockadeattenuatescardiacmyofibrillarremodellinginchronicdiabetesMolecularandCellularBiochemistryxxx:1–8,2004.接受哌道普利治疗的ZDF大鼠，其胰岛切片中增殖细胞核抗原染色阳性细胞数目增加PhivosSymeonidesa,SpyridonKoulourisb,EkateriniVratsista
Bothramiprilandtelmisartanreverseindicesofearlydiabeticcardiomyopathy:Acomparativestudy
EurJEchocardiography(2007)8,480e486

ACEI的潜在作用机制——控制血糖中位终点值ACEI抗动脉粥样硬化的机制PHYLLIS研究显示，ACEI可有效逆转颈动脉内膜中层厚度〔IMT〕达0.002mm/年ACEI对糖尿病患者的心血管保护作用具有确凿的