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利福平丝素蛋白载药微球的制备及性能研究.docx

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利福平丝素蛋白载药微球的制备及性能研究 Title:PreparationandCharacterizationofRifampicin-loadedSilkFibroinProteinMicrospheres Abstract: Theuseofmicrospheresforcontrolleddrugdeliveryhasgainedsignificantattentionduetotheiruniquepropertiesandapplications.Inthisstudy,wefocusedonthepreparationandcharacterizationofrifampicin-loadedsilkfibroinproteinmicrospheres.Silkfibroin,anaturallyderivedprotein,hasattractedattentionasapotentialdrugcarrierduetoitsbiocompatibility,biodegradability,andcontrolleddrugreleaseproperties.Themainobjectiveofthisresearchwastoinvestigatetheencapsulationefficiency,drugreleasebehavior,andphysicochemicalpropertiesofrifampicin-loadedmicrospheres,whichcanserveasafoundationforfuturedrugdeliverysystemdevelopment. Keywords:silkfibroin,proteinmicrospheres,drugdelivery,rifampicin,encapsulationefficiency 1.Introduction Microspheresaresphericalparticles,generallyranginginsizefrom1to1000μm,whichhaveattractedconsiderableattentionasaversatiledrugdeliverysystem.Theyoffernumerousadvantages,suchascontrolledreleaseofdrugs,improvedtherapeuticefficacy,reduceddosingfrequency,anddecreasedsideeffects.Silkfibroin,anaturalproteinderivedfromsilkwormcocoons,hasemergedasapromisingmaterialfordrugdeliveryduetoitsdesirableproperties,includingbiocompatibility,biodegradability,andmildprocessingconditions.Rifampicin,ananti-tuberculosisdrug,waschosenasamodeldrugforencapsulationwithinsilkfibroinproteinmicrospheresduetoitshightherapeuticefficacyandpoororalbioavailability. 2.MaterialsandMethods 2.1Materialpreparation Silkfibroinproteinwasextractedfromsilkwormcocoonsusingapreviouslyestablishedmethod.Therifampicinsolutionwaspreparedbydissolvingitinanorganicsolvent. 2.2Microspherepreparation Therifampicin-loadedsilkfibroinmicrosphereswerepreparedusingthewater-in-oilemulsionsolventevaporationtechnique.Emulsificationwasachievedbyaddingthesilkfibroinsolutiondropwiseintotheoilphasecontainingasurfactant.Theresultingemulsionwasstirredandtheorganicsolventwasevaporatedtoobtaindriedmicrospheres. 2.3Characterization T