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柴胡疏肝散对慢性胰腺炎胰腺纤维化影响的实验研究.docx

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柴胡疏肝散对慢性胰腺炎胰腺纤维化影响的实验研究 Title:ExperimentalStudyontheEffectofChaihuShuganPowderonPancreaticFibrosisinChronicPancreatitis Abstract: Chronicpancreatitisisaprevalentinflammatorydiseasethatcanprogresstopancreaticfibrosis.ManytraditionalChinesemedicineformulas,includingChaihuShuganPowder,havebeenusedtoalleviatethesymptomsandimprovetheprognosisofvariousdiseases.ThisstudyaimstoinvestigatethepotentialeffectsofChaihuShuganPowderonpancreaticfibrosisinchronicpancreatitis.Anexperimentalmodelofchronicpancreatitiswithpancreaticfibrosiswasestablishedinrats.ChaihuShuganPowderwasadministeredtothetreatmentgroup,whileaplacebowasadministeredtothecontrolgroup.Variousmarkers,includinghistopathologicalchanges,collagencontent,andexpressionoffibrogenicmarkers,wereevaluatedtoassessthedegreeofpancreaticfibrosisinthetwogroups.ResultsshowedthatChaihuShuganPowdersignificantlyreducedpancreaticfibrosisbysuppressingfibrogenesis,suggestingitspotentialasatherapeuticoptionforchronicpancreatitis. Keywords:chronicpancreatitis,pancreaticfibrosis,ChaihuShuganPowder,fibrogenesis 1.Introduction Chronicpancreatitisisaprogressiveinflammatorydiseasecharacterizedbypersistentorrecurrentabdominalpainandpancreaticdysfunction.Prolongedinflammationinthepancreascanleadtothedepositionofextracellularmatrix(ECM)components,resultinginpancreaticfibrosis(1).Pancreaticfibrosisisakeypathologicalfeatureofchronicpancreatitisandcanfurtherimpairpancreaticfunction,leadingtothedevelopmentofexocrineandendocrineinsufficiency(2).Currently,thereisnoeffectivetreatmentforpancreaticfibrosis,highlightingtheneedfornewtherapeuticapproaches. 2.ChaihuShuganPowder ChaihuShuganPowder,atraditionalChinesemedicineformula,hasbeenusedforcenturiestotreatavarietyofliver-relateddiseases,includingliverfibrosisandhepatitis(3).Thepowderiscomposedofseveralbotanicalingredients,includingBupleurumchinense,Citrusaurantium,andGlycyrrhizauralensis. 3.Methods 3.1ExperimentalModel Aratmodelofchronicpancreatitiswithpancreaticfibrosiswasestablished.Briefly,ratsweread