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柴胡疏肝散对慢性胰腺炎葡萄糖代谢的实验研究.docx

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柴胡疏肝散对慢性胰腺炎葡萄糖代谢的实验研究 Title:ExperimentalStudyontheEffectsofChaihuShuganPowderonGlucoseMetabolisminChronicPancreatitis Abstract: Chronicpancreatitisisacommongastrointestinaldisordercharacterizedbyinflammationandfibrosisofthepancreas.Glucosemetabolismabnormalities,includingimpairedinsulinsecretionandinsulinresistance,areprevalentinpatientswithchronicpancreatitis.ChaihuShuganPowder(CSP),atraditionalChineseherbalformula,hasbeenwidelyemployedinthetreatmentofdigestivesystemdiseases.TheobjectiveofthisstudywastoinvestigatetheeffectsofCSPonglucosemetabolisminaratmodelofchronicpancreatitis. Keywords:chronicpancreatitis,ChaihuShuganPowder,glucosemetabolism,insulinsecretion,insulinresistance 1.Introduction Chronicpancreatitisisachronicinflammatorydiseaseofthepancreas,whichleadstoirreversibledamagetopancreatictissueanddysfunctionoftheexocrineandendocrinepancreas.Glucosemetabolismabnormalitiesarefrequentlyobservedinpatientswithchronicpancreatitis,includingimpairedinsulinsecretionandinsulinresistance.Theseabnormalitiescontributetothedevelopmentofdiabetesmellitusandmetabolicsyndromeinthesepatients.ChaihuShuganPowder,atraditionalChineseherbalformula,hasbeenwidelyusedtotreatdigestivesystemdiseases,includingchronicpancreatitis.However,theeffectsofCSPonglucosemetabolisminchronicpancreatitisremainunclear. 2.MaterialsandMethods 2.1AnimalModel Aratmodelofchronicpancreatitiswasestablishedbyintraductaladministrationoftrinitrobenzenesulfonicacid(TNBS). 2.2GroupingandTreatment Ratswererandomlydividedintofourgroups:controlgroup,chronicpancreatitisgroup,CSPlow-dosegroup,andCSPhigh-dosegroup.RatsintheCSPgroupswereorallyadministeredwithdifferentdosesofCSPforeightweeks. 2.3BiochemicalAnalysis Bloodsampleswerecollectedattheendofthetreatmentperiodtomeasureglucoselevels,insulinlevels,andinsulinresistanceindex. 2.4HistologicalExamination Pancreatictissueswereharvestedforhistologicalexaminationtoassesstheseverityofinflammationandfibrosis. 2.5StatisticalAnalysis Datawereanalyzedusingone-wayanalysisofvar