杨梅素纳米干混悬剂制备工艺及其体内外评价的中期报告.docx

杨梅素纳米干混悬剂制备工艺及其体内外评价的中期报告
摘要：
本文介绍了杨梅素纳米干混悬剂的制备工艺及其体内外评价结果。采用沉淀法制备杨梅素纳米粒子，经过干混、分散等工艺步骤制备成纳米干混悬剂。使用光学显微镜、扫描电子显微镜等方法表征了纳米干混悬剂的形态、粒径等性质。体外释放实验表明，纳米干混悬剂具有缓释性质，并且释放速度较慢，可以长时间维持有效药物浓度。体内药代动力学实验表明，纳米干混悬剂在小鼠体内具有良好的生物利用度，并且在体内停留时间较长。细胞毒性实验表明，纳米干混悬剂在给定浓度范围内对细胞无明显毒性。因此，该杨梅素纳米干混悬剂制备工艺可行，具有良好的缓释性质和生物利用度，有望应用于临床药物研究。
关键词：杨梅素，纳米干混悬剂，制备工艺，体内外评价
Abstract:
ThispaperintroducesthepreparationprocessandinvitroandinvivoevaluationresultsofYangmeiSunanodry-mixsuspension.YangmeiSunanoparticleswerepreparedbyprecipitationmethod,andnanodry-mixsuspensionwaspreparedbyprocessstepssuchasdrymixinganddispersion.Themorphologyandparticlesizeofthenanodry-mixsuspensionwerecharacterizedbyopticalmicroscopyandscanningelectronmicroscopy.Invitroreleaseexperimentsshowedthatthenanodry-mixsuspensionhadsustained-releasepropertiesandreleasedthedrugslowly,maintaininganeffectivedrugconcentrationforalongtime.Thepharmacokineticexperimentinmiceshowedthatthenanodry-mixsuspensionhadgoodbioavailabilityandremainedinthebodyforalongtime.Thecelltoxicityexperimentshowedthatthenanodry-mixsuspensionhadnosignificanttoxicitytocellsatgivenconcentrations.Therefore,thepreparationprocessofYangmeiSunanodry-mixsuspensionisfeasible,andhasgoodsustained-releasepropertiesandbioavailability,andisexpectedtobeusedinclinicaldrugresearch.
Keywords:YangmeiSu,nanodry-mixsuspension,preparationprocess,invitroandinvivoevaluation.