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论著 狼疮性肾炎13O例临床和病理分析 张连云郭明好刘云张燕 (新乡医学院第一附属医院肾病风湿免疫科河南卫辉453100) 【摘要】目的探讨不同类型狼疮性肾炎患者的临床和病理特点。方法回顾性分析狼疮性肾炎患者128例病例资料,在B超下行肾活 检,进行病理分型。标本分别做直接免疫荧光,光镜和电镜检查,并对患者的临床表现进行分析。结果128例患者中,以Iv型最多, 62倒占48.44%l其次是V型和II型,分别为21例,12例,占16.41%和9.38%,III型、III+V型和Iv+v型相对少见,分别为13例,8例,7例, 占10.16%6.25%和5.47%。II型多表现为隐匿性肾炎lⅢ型多表现为肾炎综合征lIV型和v型多表现为肾病综合征。II型荧光沉积部位 以系膜区(Ms)为主,V型和IV+V型荧光沉积部位以肾小球毛细血管壁(GCw)为主,Ⅲ型和IV型荧光沉积部位以(6CW+Ms)为主。IV型和Ⅳ 型的AJ和cI评分要高于其他类型。结论不同类型狼疮性肾炎的临床表现和病理检查均有一定的特点,这对于狼疮性肾炎的分型诊断、 临床治疗和预后判断具有指导意义。 【关键词l系统性虹斑狼疮狼疮性肾炎肾活检病理分型 【中图分类号]R593.242I文献标识码】A【文章编号】1674-0742(2010)08(a)-0006-03 Analysis0nCliniCalandPathologicalof13OCaseswithLupusNephritis ZHANGLianyunGUOMinghaoLIUYunZHANGYan DepartmentofRenalandRheumaticInternalMedicine,thefirstaffiliatedhospitalofXinxiangMedicalCollegeWeihui。Henan453100。China [Abstract]ObjectireToexploretheclinicalandpathologicfeatureswithdifferenttypesoflupusnephritispatients.MethodsRetrospective analysis128casesmaterialofpatientswithlupusnephritis,renalbiopsyunderB-sonographydownlink,pathologicaltype.Specimens weredirectlyimmunofluorescence,lightandelectronmicroscopyexamination,andtheclinicalmanifestatj0nsofpatientswere analyzed.ResultsIVtypeisthemostof48.44%in128patients,sixty-twocases。SecondistheVandIItype,respectively21 and12casestheratesis16.41%and9.38%,typeIIIandVtypeV+IVandrelativelyrare.respectivelyl3cases,8cases,7Cases of.theratesis6.25%10.t6%,and5.47%.LatentnephritisisthemostinIItype,nephritissyndromeisthemostinⅢtype, nephroticsyndromeisthemostinVtypeandIVtype.ThedepositionareawithfluorescentoftheIItypeisalmostinmesangial (MS).ThedepositionareawithfluorescentoftheVandIV+Visalmostinglomerularcapillarywall(GCW),Thedepositionarea withfluorescentofthe11andIVtypeisalmostinglomerularcapillarywallANDmesangial(GCW+MS).theAIrateofIlland IVtypeishigherthanothertypes.ConclusionTheclinicalandpathologicalexaminationofdifferenttypeswithlupusnephritis, thishascertaincharacteristicsoflupusnephritisforclinicaldiagnosis,classifiCationandtheprognosticsignificance. [K