瑞格列奈与阿卡波糖治疗2型糖尿病临床疗效比较研究.docx

瑞格列奈与阿卡波糖治疗2型糖尿病临床疗效比较研究关键词：糖尿病2型;瑞格列奈;阿卡波糖;餐后血糖;血脂;体重指数摘要:目的比较瑞格列奈与阿卡波糖治疗2型糖尿病患者的临床疗效。方法将66名单纯饮食加运动疗法治疗不满意的2型糖尿病患者随机分为瑞格列奈组34例及阿卡波糖组32例，疗程为12周。定期测定并比较两组治疗前后空腹血糖、餐后2h血糖，糖化血红蛋白，空腹及餐后2h胰岛素，血脂和体重指数。结果瑞格列奈组FPG平均下降/L，疗效优于阿卡波糖组，两组P值均;两种药物对P2hBG均有明显地降低作用，且降低程度相似;两组A1C均能显着降低，瑞格列奈组从%降至%，阿卡波糖组从%降至%，两组比较A1C降低的幅度无显着性差异;餐后2h血清胰岛素与治疗前比较瑞格列奈组升高有显着性差异，而阿卡波糖组明显降低，治疗后12周瑞格列奈组BMI略上升%，阿卡波糖组BMI下降%，两组间比较有显着性差异。阿卡波糖能使甘油三脂和低密度脂蛋白明显降低。结论瑞格列奈和阿卡波糖均有明显降低空腹和餐后血糖以及A1C的作用，对以餐后血糖高为主的糖尿病患者更适合选用。瑞格列奈降空腹血糖的作用优于阿卡波糖，而阿卡波糖可减低餐后胰岛素分泌，调节血脂，减轻体重，更适合肥胖患者。关键词:糖尿病2型;瑞格列奈;阿卡波糖;餐后血糖;血脂;体重指数Comparativestudyonthetherapeuticefficacyofrepaglinideversusacarboseintreatmentoftype2diabetesmellituspa-tients.Abstract:ObjectiveTocompareclinicaltherapeuticefficacyoftherepaglinideandacarboseintheontype2diabetesmelliuspatients.MethodsSixtysixpatientswithtype2diabetesmellitus，wererandomlydividedintotwogroupsandtreatedfor12weekseitherwithrepaglinideoracarbose，valuesofFPG，P2hBG，A1C，FINS，P2hINS，blood-fatandBMIwereperiodicallymeasuredandcomparedbeforeandaftertreatment.ResultsTheconcentrationsofFPGdecreasedbothinrapaglinidegroupandacarbosegroup.BothdrugscouldreducethevalueofP2hBGsignificantly，whichhadsimilareffectsaslevelsofA1Cweresig-nificantlydecreasedintwogroups，theconcentrationsofA1Creduced±）%to%inra-palinidegroup，andfrom%to%inacarbosegroup，butwithoutstatisticallysignificantdifference.ThevaluesofP2hINSweresignificantlyincreasedascomparedwiththoseinrapalinidegroupbeforetreatment，butweresignificantlydecreasedinacarbosegroupAftertreatment，BMIwasslightlyincreased%inrapalinidegroupanddecreased%inacarbose，showingsignificantdifferencebetweenthetwogroups.ConclusionThevaluesofFPG，P2hBGandA1CweresignificantlydecreasedinbothandacarbosearemoresuitablefortreatmentofpatientswhosevalueofP2hBGwereincreasedapparentlyaftereffectsofrapaglinideisbetterthanacarboaeinreducehastheeffectofreducingpostprandialinsulinsecretion，regulatingblood-fatandlosingbodyweight，thusismoresuitabletoobesetype2diabetics.Keywords:Type2diabetesmellitus;Rapaglinide;Aca