miRNA和lncRNA相关SNPs数据库及其在肿瘤研究中的应用.pdf

2U2U年12月15H弟43卷弟6期intJGenetDec.15.2020,Vol.34，l\o.6•353••32^•miRNA和IncRNA相关SNPs数据库及其在肿瘤研究中的应用莫晗杨祎张学龙“21哈尔滨医科大学医学遗传学研究室150081;2中国遗传资源保护与疾病防控教育部重点实验室（哈尔滨医科大学）150081通信作者：张学龙，Email:[e-mail]•edu.cn【摘要】微小RNA(microRNA,miRNA)是基因表达的关键调节因子。而长链非编码RNA(longnon-codingRNA，IncRNA)作为内源竞争RNA(competingendogenousRNA，ceRNA)，与mRNA竞争结合miRNA。miRNA靶标种子区域或者IncRNA上与miRNA结合区域的单核苷酸多态（singlenucleotidepolymorphism，SNP)的存在，可能影响miRNA与mRNA以及IncRNA与miRNA的结合，从而影响靶基因的表达水平和肿瘤的形成。随着IncRNA和miRNA相关SNPs被不断发现，后续的功能分析及其与人类疾病的关系等研究内容不断进展，对大量数据进行整合和分析并对相关SNPs进行分类就显得尤为重要，由此诞生了众多的SNPs数据库。本文将从基本注释信息内容，相关功能分析和简单应用等方面回顾常用的IncRNA和miRNA相关的SNPs数据库，为研究人员提供参考。【关键词】长非编码RNA;微小RNA;单核苷酸多态；数据库；肿瘤基金项目：国家自然科学基金（81373220)D0I：10.3760/cma.j.cn231536-20200816-00071MicroRNA-andIncRNA-relatedSNPsdatabaseanditsapplicationincancerresearchMoHan2,YangYi1'2,ZhangXuelong1'2'LaboratoryofMedicalGenetics,HarbinMedicalUniversity,Harbin150081,China；2KeylaboratoryofpreservationofhumangeneticresourcesanddiseasecontrolinChina(HarbinMedicalUniversity),MinistryofEducation,Harbin150081,ChinaCorrespondingauthor：ZhangXuelong,Email：[e-mail]【Abstract】MicroRNA(miRNA)isakeyregulatorofgeneexpression•Thelongnon-codingRNA(IncRNA),asacompetingendogenousRNA(ceRNA),competeswithinRNAtobindmiRNA.Thepresenceofsinglenucleotidepolymorphisms(SNPs)inthemiRNAtargetseedregionorthemiRNAbind­ingregiononIncRNAmayaffectthebindingofmiRNAtomRNAorIncRNAtomiRNA,therebyaffectingtheexpressionleveloftargetgenesandtumorformation.WiththecontinuousdiscoveryofIncRNAandmiRNA-relatedSNPs,subsequentfunctionalanalysis,itsrelationshipwithhumandiseasesandthecontinu­ousdevelopmentofotherresearchcontents,itisparticularlyimportanttointegrateandanalyzealargea-mountofdataandclassifyrelatedSNPs,whichledtothebirthofNumerousSNPsdatabase.ThisarticlereviewsthecommonlyusedIncRNAandmiRNA-relatedSNPsdatabasesintermsofbasicannotationinfor­mationcontent,relatedfunctionalanalysisandsimpleapplications,andprovidesreferencesforresearchers.【Keywords】LncRNA;MiRNA;SNP;Database;CancerF