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基于GABA受体的药物设计GABA(g-aminobutyricacid)PicrodendrinHomologuesPhenylpyrazolesTrioxabicyclooctanesButylbenzoates[3H]EBOBInhibitionof[3H]EBOBBindingLC50rat=1.41mMLC50fly=2.90mMBicyclicGABAAntagonistsNematocidalActivityLD50=24.7mMLC50rat/LC50housefly=2360nM/45nM=52(invitro)Compound152023/12/12PresumptionofBindingSitesCompound14LowestEnergyConformationofCompound14AlignmentofTheTrainingSetHouseflyGABAreceptorisoneoftheimportanttargetfordevelopinginsecticides.ElectrophysiologicalbiochemicalandpharmacologicalstudieshaveindicatedthatanumberofdifferencesexistbetweeninsectandvertebrateGABAreceptors.Exploringsuchdifferencesby3DQSARmaydevelopsaferinsecticide.欢迎合作共同发展。THANKS!