不同品种花椒药效比较研究.doc

不同品种花椒药效比较研究李惠勇刘友平李旻张玲范婧娴（成都中医药大学成都610075）摘要目的：比较花椒和青椒的主要药效作用。方法：采用番泻叶致小鼠急性腹泻实验观察花椒的抗腹泻作用；采用小鼠扭体法实验观察其镇痛作用；采用炭末推进法观察其对正常小鼠小肠运动的影响。结果：对番泻叶致小鼠急性腹泻花椒、青椒均有显著的抗腹泻作用且花椒较青椒作用强；对醋酸所致疼痛花椒有显著的镇痛作用青椒镇痛作用不明显。花椒和青椒均能抑制正常小鼠的小肠推进运动且花椒作用明显强于青椒。结论：花椒和青椒均有明显的抗腹泻、抑制小鼠小肠推进运动作用且花椒作用较强；花椒有明显的镇痛作用青椒镇痛作用不明显。关键词花椒；青椒；抗腹泻；镇痛；小肠推进StudyonefficacyofdifferentvarietiesofChinesepricklyashLIHui-yongLIUYou-pingLIMingZHANGLingFANJing-xian(ChengduUniversityofTCMchengdu610075China)Abstract:Object:Tocomparethemainefficacyofzanthoxylumbungeanummaximandz.schinifoliumsieb.etzucc.Methods:SennaisusedtomicetoacutediarrheaChinesepricklyashexperimentalobservationoftheanti-diarrhea;writhinginmicebyusingexperimentalobservationofitsanalgesiceffectattheendofpromotingtheuseofcarbonobservedinnormalmiceontheimpactofsmallbowelmovement.Results:Sennaonthemousecausedbyacutediarrhoeazanthoxylumbungeanummaximandz.schinifoliumsieb.etzucchavesignificantroleintheanti-diarrheaandzanthoxylumbungeanummaximstrongerrolethanz.schinifoliumsieb.etzucc;thepaincausedbyaceticacidthetwohavesignificantanalgesiceffectz.schinifoliumsieb.etzuccandanalgesiceffectsisnotobvious.Zanthoxylumbungeanummaximandz.schinifoliumsieb.etzucc.innormalmicecouldinhibitthemovementpromotingthesmallintestineandthefronteffectisstrongerthanthelatter.Conclusion:Zanthoxylumbungeanummaximandz.schinifoliumsieb.etzuccareobviouslyanti-diarrheaintestinalinhibitedmiceandpepperroleinpromotingthemovementstrongerrole;thefronthasclearanalgesiceffectthelatteranalgesiceffectwasnotobvious.Keywords:Zanthoxylumbungeanummaximz.schinifoliumsieb.etzuccanti-diarrhea;analgesia;intestinalpropulsion花椒为芸香科花椒属植物花椒（ZanthoxylumBungeanumMaxim）和青椒（Z.SchinifoliumSieb.etZucc.）的干燥成熟果皮[1]是常用的温里药。花椒入药最早见于《神农本草经》认为花椒可以“坚齿发”、“耐老”、“增年”。现收载于《中国药典》2005年版一部中功效为“温中止痛、杀虫止痒”。临床用于治