芪味糖平胶囊干预治疗糖耐量受损的临床研究.docx

芪味糖平胶囊干预治疗糖耐量受损的临床研究[摘要]目的：观察芪味糖平胶囊干预治疗糖耐量受损（IGT）患者对糖尿病（DM）发病率的作用以及逆转为正常糖耐量（NGT）的作用。方法：以口服75g葡萄糖耐量试验（OGTT）作为筛选条件按1999年WHO诊断标准选取我院100例IGT患者并对其进行2年前瞻性研究。将所有患者随机分为试验组与对照组每组50例。入选患者不被干预其生活方式只对其进行一般的IGT知识宣教。试验组给予口服芪味糖平胶囊治疗每次3粒每日2次；对照组给予口服芪味糖平胶囊模拟剂治疗每次3粒每日2次。疗程为24个月。结果：治疗2年后试验组由IGT转为DM者为4.17%对照组为25.53%；试验组由IGT转为NGT者为50.00%对照组为17.02%；两组比较差异有统计学意义（P＜0.01）。结论：芪味糖平胶囊有改善胰岛素抵抗和胰岛β细胞功能的作用芪味糖平胶囊干预治疗IGT是预防IGT向2型DM发展的有效措施。[关键词]糖耐量受损；糖尿病；干预治疗；芪味糖平胶囊；临床研究[中图分类号]R259[文献标识码]A[文章编号]1673-7210（2011）04（a）-101-03ClinicalstudyonQiweiTangpingCapsuleinthetreatmentofimpairedglucosetoleranceYANGLibo1CHENYanjun2WANGBaoqun3CHENXueling31.HebeiYilingInstituteofMedicineShijiazhuang050035China;2.TheSecondHospitalofZhangjiakouCityHebeiProvinceZhangjiakou075000China;3.Workers'HospitalAffiliatedtoHebeiNormalUniversityShijiazhuang050091China[Abstract]Objective:ToevaluatetheeffectsofQiweiTangpingCapsuleonconversiontoDMorNGTinIGTpatients.Methods:Inthis2yearsprospectivestudy100patientswithIGTwereincluded.IGTwasdefinedby1999WHOcriteriainthemethodofutilizing75goralglucosetolerancetest(OGTT).Allpatientswererandomlydividedintothetreatmentgroup(50cases)andcontrolgroups(50cases).Theirlifewayweren'tintervenedbutonlyweregivenIGTknowledgeeducation.ThetreatmentgroupwasgivenQiweiTangpingCapsuleatthedoseof3Capsule(twiceperday)andthecontrolgroupwasgivenPlaceboCapsuleatthedoseof3Capsule(twiceperday).Thestudylastedfor24months.Results:TheratioofIGTwhichconvertedtoDMwas4.17%intreatmentgroupand25.53%incontrolgroupandtheratioofIGTwhichconvertedtoNGTwas50.00%intreatmentgroupand17.02%incontrolgroup(P＜0.01).Conclusion:InterventiontreatmentwithQiweiTangpingCapsuleisoneoftheeffectivemeasuresinpreventingtheconversionofIGTtoDM.[Keywords]IGT;DM;Interventio