吡格列酮联合缬沙坦治疗早期糖尿病肾病疗效观察.docx

吡格列酮联合缬沙坦治疗早期糖尿病肾病疗效观察[摘要]目的探讨吡格列酮与缬沙坦联合治疗早期糖尿病肾病的临床疗效。方法将56例早期糖尿病肾病患者分成治疗组（30例）和对照组（26例）对照组采用缬沙坦单一治疗治疗组采用吡咯列酮与缬沙坦联合治疗比较两组24h尿微量白蛋白（24hMALB）、空腹血糖（FPG）、收缩压（SBP）、糖化血红蛋白（HbA1c）和C反应蛋白（CRP）的变化。结果与治疗前比较两组治疗后24hMALB、HbA1c均有下降（均P＜0.05）治疗后治疗组与对照组24hMALB（t=2.023）、FPG（t=2.440）、HbA1c（t=2.139）疗效比较差异均有统计学意义（均P＜0.05）。结论吡格列酮与缬沙坦联合应用是治疗早期糖尿病肾病有效的方法。[关键词]早期糖尿病肾病；吡格列酮；缬沙坦；24h尿微量白蛋白[中图分类号]R587.2[文献标识码]A[文章编号]1673-7210（2012）01（b）-093-02ObservationofcurativeeffectsonPioglitazonecombinedwithValsartaninthetreatmentofearlydiabeticnephropathySONGQuanchaoWANGSihongXIAOHoushengDepartmentofEndocrinologyXuanchengPeople'sHospitalAnhuiProvinceXuancheng242000China[Abstract]ObjectiveToinvestigatethecurativeeffectsofPioglitazonecombinedwithValsartaninthetreatmentofearlydiabeticnephropathy.Methods56patientswithearlydiabeticnephropathyweredividedintotreatmentgroup(30cases)andcontrolgroup(26cases).ThecontrolgroupwasgivenValsartanonlyandthetreatmentgroupwasgivenPioglitazonecombinedwithValsartan.The24-hoururinemicroalbumin(24hMALB)fastingplasmaglucose(FPG)systolicbloodpressure(SBP)glycosylatedhemoglobin(HbA1c)andC-reactiveprotein(CRP)changesofthetwogroupswerecompared.ResultsComparedwithbeforetreatmentthe24hMALBandHbA1caftertreatmentweredecreasedinbothgroups(allP＜0.05).Aftertreatmentthecurativeeffectsdifferencesinthe24hMALB(t=2.023)FPG(t=2.440)andHbA1c(t=2.139)betweenthetreatmentgroupandcontrolgroupwerestatisticallysignificant(allP＜0.05).Conclusion:PioglitazonecombinedwithValsartaniseffectiveinthetreatmentofearlydiabeticnephropathy.[Keywords]Earlydiabeticnephropathy;Pioglitazone;Valsartan;24-hoururinemicroalbumin我国糖尿病（diabetesmellitusDM）发病率逐年升高糖尿病肾病（diabeticnephropathyDN）是糖尿病常见的慢性微血管并发症之一DN引发的终末期肾功能衰竭成为威胁DM患者生命的重要原因。积极的早期干预治疗可明