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Pickering乳液在制备药物胶囊中的应用.docx

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Pickering乳液在制备药物胶囊中的应用 Title:ApplicationofPickeringEmulsioninthePreparationofPharmaceuticalCapsules Abstract: Pickeringemulsion,atypeofemulsionstabilizedbysolidparticlesattheoil-waterinterface,hasattractedsignificantattentioninrecentyearsduetoitsuniquepropertiesandpotentialapplications.Inthepharmaceuticalindustry,theuseofPickeringemulsionhasgainedinterestasapromisingalternativeforthepreparationofdrug-loadedcapsules.ThispaperaimstoexploretheapplicationofPickeringemulsioninpharmaceuticalcapsuleformulationanddiscussitsadvantagesandchallenges. 1.Introduction Theconventionalmethodofpreparingpharmaceuticalcapsulesinvolvestheuseofsurfactantsandpolymersasemulsifyingagents.However,theseagentsmayhavelimitations,suchasinstability,toxicity,orallergenicity.Pickeringemulsion,ontheotherhand,offersapromisingalternativeasitisstabilizedbysolidparticles,whichcanprovideenhancedstability,controlledrelease,andimprovedoverallperformance. 2.FormationofPickeringEmulsion Pickeringemulsioncanbepreparedbyvariousmethods,includinghigh-energyemulsification,spontaneousemulsification,andphaseinversionmethods.Solidparticles,suchassilica,clay,ornanoparticles,areusedasstabilizers.Thechoiceofparticlesandtheirsurfacemodificationcaninfluencethestability,dropletsize,anddrugreleasekineticsoftheresultingemulsion. 3.AdvantagesofPickeringEmulsioninPharmaceuticalCapsules a)Enhancedstability:ThesolidparticlesinPickeringemulsionprovideaphysicalbarrierthatpreventscoalescenceandmaintainsthestabilityoftheemulsionforextendedperiods. b)Controlleddrugrelease:Thesolidparticlesattheinterfacecancontrolthereleaserateoftheencapsulateddrugbyactingasdiffusionbarriersorbymodifyingsurfaceproperties. c)Reductionoftoxicorallergenicagents:Theuseofsolidparticleseliminatestheneedforsurfactantsorpolymersthatmayhavetoxicityorallergenicityconcerns. d)Increaseddrugloading:Thehighsurfaceareaofthesolidparticlesallowsforincreaseddrug-loadingcapacityinthePickeringemulsion,enablingtheencapsulationofahigheramountofdrugs. 4.ChallengesandLimit