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代谢组学研究癌症代谢机制、纳米毒性和疾病标志物的开发（英文）.docx

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代谢组学研究癌症代谢机制、纳米毒性和疾病标志物的开发（英文） AResearchonMetabolomics:UnderstandingCancerMetabolismMechanisms,Nanotoxicity,andDiseaseBiomarkerDevelopment Introduction: Cancerhasalwaysbeenamajorglobalhealthissue,affectingmillionsofpeopleworldwide.Innovativeapproacheslikemetabolomicshaveemergedaspromisingtoolsincancerresearch.Metabolomicsfocusesonstudyingthemetabolicbiomarkersandpathwaysassociatedwithcancer,enablingadeeperunderstandingofcancermetabolismmechanismsandthedevelopmentofnewdiagnosticandtherapeuticstrategies.Furthermore,metabolomicsalsoplaysacrucialroleinnanotoxicology,assessingthesafetyandefficacyofnanomaterialsincancertreatment.Thispaperaimstoexploretheroleofmetabolomicsincancerresearch,includingunderstandingcancermetabolismmechanisms,investigatingnanotoxicity,anddevelopingdiseasebiomarkers. UnderstandingCancerMetabolismMechanisms: Metabolismisthesetofchemicalreactionsthatoccurwithincellstosustainlife.Cancercellsexhibitalteredmetabolismcomparedtonormalcells,aphenomenonknownastheWarburgeffect.Metabolomicsisusedtostudytheuniquemetaboliteprofilesofcancercellstoidentifythemetabolicpathwaysthatcontributetocancerdevelopmentandprogression.Byanalyzingthemetabolicsignaturesofcancercells,researcherscanuncoverspecificmetabolicalterationsthatcanbetargetedfortherapy.Additionally,metabolomicsalsohelpsinunderstandingthemetabolicadaptationsthatenablecancercellstosurviveinvariousmicroenvironments,leadingtoinsightsintotumorheterogeneityanddrugresistance. NanotoxicityAssessment: Theuseofnanomaterialsincancertherapyhasshowntremendouspotential.However,thesafetyandtoxicityofthesenanomaterialsneedtobecarefullyevaluatedbeforeclinicaltranslation.Metabolomicsprovidesacomprehensiveunderstandingofthemetabolicchangesinducedbynanomaterials,sheddinglightontheirpotentialtoxicity.Byanalyzingthemetabolicprofilesofcellsororganismstreatedwithnanomaterials,researcherscanidentifyanyadverseeffectsoncellularmetabolism.Hence,metabolomicsservesasavaluabletoolinnanotoxicityassessmentsofnanomaterials,ensuringtheir