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盲肠灌注丙酸钠对生长猪肠道菌群及食欲的影响.docx

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盲肠灌注丙酸钠对生长猪肠道菌群及食欲的影响 Title:TheEffectsofSodiumPropionateAppendedIlealPerfusiononGutMicrobiotaandAppetiteinGrowingPigs Abstract: Thepresentstudyinvestigatestheimpactofsodiumpropionateappendedilealperfusiononthegutmicrobiotaandappetiteingrowingpigs.AtotalofXXgrowingpigswereallocatedtotwodifferenttreatments,includingcontrol(waterperfusion)andsodiumpropionate(0.3%sodiumpropionatesolutionperfusion)foradurationofXXdays.Thestudyfocusedonevaluatingchangesinmicrobialcommunitieswithinthegutanditspotentialimpactonappetiteregulation.Additionally,feedintake,bodyweightgain,andotherphysiologicalparametersweremeasuredtoassesstheoveralleffectsofsodiumpropionateongrowingpigs. Introduction: Theintestinalmicrobiotaplaysacrucialroleinhosthealthandcontributestodigestion,immunesystemregulation,andnutrientmetabolism.Manipulatinggutmicrobiotaviacertaintreatmentsmayhavethepotentialtoimproveanimalhealthandproductivity.Sodiumpropionate,acommonfeedadditive,hasbeenshowntohaveantimicrobial,anti-inflammatory,andimmune-modulatoryproperties.Thisstudyaimstoelucidatetheeffectsofsodiumpropionateappendedilealperfusiononthegutmicrobiotacompositionandappetiteingrowingpigs. Methods: -ExperimentalDesign:AtotalofXXgrowingpigswererandomlyallocatedintotwogroups,includingcontrol(waterperfusion)andsodiumpropionate(0.3%sodiumpropionatesolutionperfusion). -IlealPerfusion:Pigsinthesodiumpropionategroupreceivedilealperfusionof0.3%sodiumpropionatesolution,whilethecontrolgroupreceivedanequivalentvolumeofwater. -Sampling:Fecalsampleswerecollectedatvarioustimepointsbeforeandaftertheperfusion.Thesampleswereanalyzedformicrobialcompositionusinghigh-throughputDNAsequencing. -MeasurementofAppetite:Feedintake,foodpreference,andotherparametersrelatedtoappetitestimulationwererecordedthroughoutthestudy. -StatisticalAnalysis:Datawereanalyzedusingappropriatestatisticalmethodstodeterminesignificantdifferencesbetweenthecontrolandsodiumpropionategroups. Results: -GutMicrobiotaComposition:Analysisofthefecalsamplesrevealedsignificantal