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盲肠灌注丙酸钠对猪肠道及机体代谢的影响.docx

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盲肠灌注丙酸钠对猪肠道及机体代谢的影响 Title:TheEffectsofSodiumPropionateAppendicealInfusiononPorcineIntestinalandMetabolicResponses Abstract: Theappendixisavestigialorganinhumansbutremainsafunctionalcomponentofthegastrointestinaltractinseveralmammalianspecies,includingpigs.Emergingevidencesuggeststhatsodiumpropionate,ashort-chainfattyacid,maypossessbeneficialeffectsonguthealthandmetabolicregulation.Thisstudyaimstoinvestigatetheeffectsofsodiumpropionateappendicealinfusiononporcineintestinalandmetabolicresponses.Theresultsofthisresearchcouldyieldvaluableinsightsintothepotentialtherapeuticapplicationsofsodiumpropionateinpromotingguthealthandmetabolichomeostasis. Introduction: Thegutmicrobiotaplaysacriticalroleinmaintainingintestinalhomeostasisandmetabolicregulation.Short-chainfattyacids(SCFAs),includingpropionate,acetate,andbutyrate,arethemajorproductsofmicrobialfermentationinthegut.Theyexertdiverseeffectsonintestinalintegrity,immunefunction,andenergymetabolism.Sodiumpropionate,asthesodiumsaltofpropionicacid,hasbeenexploredforitspotentialtherapeuticbenefitsinvariousmetabolicdisorders.However,littleisknownabouttheeffectsofsodiumpropionateappendicealinfusionontheintestinalandmetabolicresponsesinpigs. Methods: 1.AnimalModel:Healthyadultpigswereselectedandallocatedintotwogroups:controlandsodiumpropionateinfusion. 2.SurgicalProcedure:Thepigsunderwentasepticsurgicalprocedureforappendicealcannulationandinfusion. 3.SodiumPropionateInfusion:Theanimalsinthetreatmentgroupreceivedsodiumpropionateinfusionthroughtheappendicealcannulaforapredeterminedperiod. 4.Sampling:Intestinalsamplesandbloodspecimenswerecollectedatspecifictimepointsbeforeandaftertheinfusionforvariousanalyses. Results: 1.IntestinalMorphology:Thehistologicalanalysisrevealedimprovedintestinalmucosalintegrityandreducedinflammationinthesodiumpropionateinfusiongroupcomparedtothecontrolgroup. 2.GutMicrobiota:Sodiumpropionateinfusionpromotedashiftinthegutmicrobiomecompositiontowardsamorebeneficialprofile,characterizedbyanincreasedabundance