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氧化石墨烯对肠上皮细胞自噬的影响及其机制探究.docx

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氧化石墨烯对肠上皮细胞自噬的影响及其机制探究 Title:ExploringtheEffectsofGrapheneOxideonAutophagyinIntestinalEpithelialCells:MechanisticInsights Abstract: Autophagy,ahighlyconservedcellularprocess,playsacrucialroleinmaintainingcellularhomeostasisbyrecyclingdamagedorganellesandproteins.Dysregulationofautophagyhasbeenimplicatedinthepathogenesisofvariousdiseases,includinggastrointestinaldisorders.Grapheneoxide(GO),atwo-dimensionalnanomaterial,hasgainedsignificantattentionduetoitsuniquephysicochemicalpropertiesandpotentialbiomedicalapplications.ThisreviewaimstoinvestigatetheimpactofGOonautophagyinintestinalepithelialcellsandelucidatetheunderlyingmechanisms. Introduction: Thegastrointestinal(GI)tractislinedwithasinglelayerofintestinalepithelialcellsthatformacriticalbarrierbetweentheexternalenvironmentandtheunderlyingtissues.Autophagyisknowntobeessentialforthemaintenanceofintestinalepithelialcellfunction,includingdefenseagainstpathogens,regulationofinflammatoryresponses,andmodulationofbarrierintegrity.Theadventofnanotechnologyhasenabledtheexploitationofvariousnanomaterialsforpotentialtherapeuticapplications,includingGO.However,theimpactofGOonautophagyinintestinalepithelialcellsremainspoorlyunderstood. Methods: ToexploretheeffectsofGOonautophagyinintestinalepithelialcells,acomprehensivereviewofexistingliteraturewasconducted.PubMed,WebofScience,andGoogleScholardatabasesweresearchedusingrelevantkeywords.StudiesinvestigatingtheimpactofGOonautophagyinintestinalepithelialcellswereincludedintheanalysis.Mechanisticinsightsweresummarizedbasedonthereportedfindings. Results: StudieshaveindicatedthatGOexposurecanmodulateautophagyinintestinalepithelialcells.GO-inducedautophagyactivationhasbeenobservedinvariouscelltypes,includingCaco-2cells,awidelyusedintestinalepithelialcellline.GOexposurehasbeenshowntoupregulateautophagy-relatedgenesandproteinexpression,aswellasincreasetheformationofautophagosomes.Moreover,GOtreatmenthasbeenreportedtopromoteautophagicflux,leadingtoincreasedautophagicdegradation.Thesefindin