预览加载中，请您耐心等待几秒...

一类小核仁RNA加工来源长非编码RNAs的加工成熟和功能机制研究.docx

预览
1/2
2/2

在线预览结束，喜欢就下载吧，查找使用更方便

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

一类小核仁RNA加工来源长非编码RNAs的加工成熟和功能机制研究 Title:MechanismsofProcessing,Maturation,andFunctionofLongNon-codingRNAsDerivedfromaClassofSmallNucleolarRNA Abstract: Longnon-codingRNAs(lncRNAs)haveemergedasimportantregulatorymoleculesinvolvedinvariouscellularprocesses.Amongthese,asubclassofsmallnucleolarRNA(snoRNA)-derivedlncRNAshasattractedsignificantattention.TheselncRNAsareprocessedandmaturedbythesmallnucleolarribonucleoproteincomplexandplaycrucialrolesingeneexpression,chromatinremodeling,andproteinmodification.Thisreviewexplorestheprocessing,maturation,andfunctionalmechanismsofsnoRNA-derivedlncRNAs,sheddinglightontheirpotentialastherapeutictargetsandbiomarkers. Introduction: Recentadvancesintranscriptomeanalysishaverevealedalargenumberofnon-codingRNAsthatdonotencodeproteins.LncRNAshaveemergedasadiverseclassoffunctionaltranscriptsthatregulategeneexpressionatvariouslevels.OneintriguingsubclassoflncRNAsisderivedfromsmallnucleolarRNAs(snoRNAs),whichprimarilyfunctioninribosomalRNA(rRNA)modifications.ThesesnoRNA-derivedlncRNAsexhibituniqueprocessingandmaturationmechanisms,andemergingevidencesuggeststheirimportanceincellularphysiologyandpathology. ProcessingandMaturationofsnoRNA-derivedlncRNAs: Thesmallnucleolarribonucleoprotein(snoRNP)complex,consistingofsnoRNAsandassociatedproteins,playsacriticalroleinsnoRNAbiogenesisandfunction.RecentstudieshaverevealedthatthesnoRNPcomplexalsoprocessesandmaturesasubsetofsnoRNAsintolncRNAs.Thisprocessinginvolvesvarioussteps,includingtranscription,trimming,splicing,andmodification.TheresultingsnoRNA-derivedlncRNAsoftenundergofurtherprocessingandmaturation,suchas3'endpolyadenylationandcapaddition. FunctionalMechanismsofsnoRNA-derivedlncRNAs: SnoRNA-derivedlncRNAsexhibitdiversefunctionalmechanisms.Firstly,theycanactasRNAguides,utilizingstructuralmotifswithintheirsequencestodirectthesnoRNA-bindingproteinstospecificgenomiclociandregulaterRNAmodification.Secondly,snoRNA-derivedlncRNAscanactasmolecularscaffolds,bringingtogethermultipleproteinsandformingdy