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ID2负向调控抗病毒免疫信号通路的机制研究.docx

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ID2负向调控抗病毒免疫信号通路的机制研究 Title:MechanismsofID2-mediatedNegativeRegulationofAntiviralImmuneSignalingPathways Abstract: Theintricateinterplaybetweenvirusesandthehostimmunesystemdeterminestheoutcomeofviralinfections.Theproperactivationofantiviralimmunesignalingpathwaysiscrucialformountinganeffectiveimmuneresponseagainstinvadingviruses.However,viruseshavealsoevolvedmechanismstoevadeorsuppressthehostimmuneresponses.ID2,amemberoftheinhibitorofDNAbinding(ID)proteinfamily,hasrecentlyemergedasanegativeregulatorofantiviralimmunesignalingpathways.ThisreviewaimstosummarizeanddissectthemechanismsunderlyingID2-mediatednegativeregulationofantiviralimmunesignalingpathways,specificallyfocusingontheintricatecrosstalkbetweenID2andkeyplayersintheantiviralimmuneresponse. 1.Introduction 1.1Background 1.2Objectives 2.AntiviralImmuneSignalingPathways 2.1InnateImmuneResponse 2.2AdaptiveImmuneResponse 3.ID2:AnOverview 3.1StructureandFunction 3.2ExpressionPattern 3.3TheRoleofID2inDevelopmentandHomeostasis 4.ID2-mediatedNegativeRegulationofAntiviralImmuneSignalingPathways 4.1InterplayBetweenID2andInnateImmunePathways 4.1.1Toll-likeReceptor(TLR)SignalingPathway 4.1.2RIG-I-likeReceptor(RLR)SignalingPathway 4.1.3NOD-likeReceptor(NLR)SignalingPathway 4.2InterplayBetweenID2andAdaptiveImmunePathways 4.2.1TcellReceptor(TCR)SignalingPathway 4.2.2BcellReceptor(BCR)SignalingPathway 5.MechanismsofID2-mediatedNegativeRegulation 5.1transcriptionalRegulation 5.1.1SuppressionofKeyTranscriptionFactors 5.1.2ModulationofEpigeneticChanges 5.2Protein-ProteinInteractions 5.2.1ID2InteractionwithSignalingMolecules 5.2.2ID2InteractionwithKeyImmuneRegulators 6.ClinicalSignificanceofID2-mediatedNegativeRegulation 6.1ID2asaPotentialTherapeuticTarget 6.2ID2asaPrognosticMarker 7.FuturePerspectivesandConclusion 7.1UnansweredQuestions 7.2PotentialResearchDirections Inconclusion,ID2playsacriticalroleinthenegativeregulationofantiviralimmunesignalingpathways,contributingtotheimmuneevasionstrategiesofviruses.Elucidatingthemechanis