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MiRNA--587在肝细胞癌中的功能及其作用机制的研究.docx

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MiRNA--587在肝细胞癌中的功能及其作用机制的研究 Title:TheFunctionalRolesandMechanismsofMiRNA-587inHepatocellularCarcinoma Abstract: Hepatocellularcarcinoma(HCC),themostcommontypeoflivercancer,isaglobalhealthconcernduetoitshighmorbidityandmortalityrates.MiRNAshaveemergedaskeyregulatorsincancerdevelopmentandprogression,includingHCC.ThisstudyfocusesonthefunctionalrolesandunderlyingmechanismsofMiRNA-587inHCC.ExtensiveresearchhasdemonstratedthedysregulationofMiRNA-587inHCC,suggestingitspotentialasadiagnosticandprognosticbiomarker.Additionally,MiRNA-587hasbeenimplicatedinseveraloncogenicprocessesinHCC,suchascellproliferation,apoptosis,migration,invasion,andangiogenesis.Theunderlyingmolecularmechanismsinvolvethetargetingofmultipledownstreamgenesandsignalingpathways.UnderstandingthefunctionalrolesandmechanismsofMiRNA-587inHCCcouldleadtothedevelopmentofnoveltherapeuticstrategiesandimprovepatientoutcomes. 1.Introduction: Hepatocellularcarcinoma(HCC)istheleadingcauseofcancer-relateddeathsworldwide,predominantlyaffectingindividualswithchronicliverdisease.Despiteadvancesindiagnosisandtreatment,theoverallprognosisforHCCremainspoor,necessitatingfurtherinvestigationintothemolecularmechanismsunderlyingitsdevelopmentandprogression.MiRNAs,smallnon-codingRNAs,havebeenshowntoplaycrucialrolesinvariousbiologicalprocesses,includingcancer.Inthisstudy,wefocusonMiRNA-587anditssignificanceinHCC. 2.DysregulationofMiRNA-587inHCC: NumerousstudieshavereporteddysregulatedexpressionlevelsofMiRNA-587inHCCtissuesandserum,implicatingitspotentialroleasadiagnosticandprognosticbiomarker.AlteredexpressionofMiRNA-587inHCCisassociatedwithtumorsize,differentiation,TNMstage,andoverallsurvival.UnderstandingthefunctionalconsequencesofMiRNA-587dysregulationinHCCcouldprovidevaluableinsightsintoitsroleintumorigenesisanddiseaseprogression. 3.FunctionalRolesofMiRNA-587inHCC: MiRNA-587hasbeenreportedtoexertoncogenicortumor-suppressiveeffectsinHCC,dependingonthespecificcontext.ExperimentalevidencesuggeststhatMiRNA-587promotescellprolifer