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光学相干层析成像图像中角膜厚度的自动测量方法.docx

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光学相干层析成像图像中角膜厚度的自动测量方法 Title:AutomatedMeasurementMethodforCornealThicknessinOpticalCoherenceTomographyImages Abstract: OpticalCoherenceTomography(OCT)hasemergedasavaluableimagingtechniqueinophthalmology,allowinghigh-resolutionimagingofthecornea.Inthisstudy,weproposeanautomatedmethodformeasuringcornealthicknessinOCTimagesusingopticalcoherencetomography. Introduction: Thecorneaisatransparenttissueatthefrontoftheeyethatplaysacrucialroleinvision.Theaccuratemeasurementofcornealthicknessisessentialforthediagnosisandmanagementofvariousoculardiseases,suchaskeratoconusandglaucoma.Opticalcoherencetomography(OCT)isanon-invasiveimagingtechniquethatprovideshigh-resolutioncross-sectionalimagesofocularstructures.However,manualmeasurementofcornealthicknessinOCTimagesistime-consumingandpronetointer-observervariability.Therefore,anautomatedandaccuratemeasurementmethodishighlydesirable. Methodology: TheproposedautomatedmeasurementmethodforcornealthicknessinOCTimagesconsistsofthefollowingsteps: 1.Pre-processing:TheOCTimageispre-processedtoenhancethecornealboundaryandreducenoise.ThiscanbeachievedbyapplyingaGaussianfiltertosmoothentheimageandusingedgedetectionalgorithmstodetectthecornealboundaries. 2.Segmentation:Thecorneaissegmentedfromtherestoftheimagetoisolatetheregionofinterest.Thisstepcanbeperformedusingvarioussegmentationalgorithms,suchasthresholding,region-growing,oractivecontourmodels. 3.Boundarydetection:Thecornealboundariesaredetectedtoextractthecornealsurfaces.Thiscanbeachievedbyapplyingedgedetectionalgorithmsalongthecornealsurface,suchastheCannyedgedetectionalgorithmortheSobeloperator. 4.Surfacefitting:Thedetectedcornealboundariesarefittedusingmathematicalmodels,suchassplinesorcurves,toobtainasmoothrepresentationofthecornealsurfaces.Thisallowsforaccuratemeasurementofcornealthicknessatanypointalongthecornealsurface. 5.Thicknessmeasurement:Thecornealthicknessismeasuredasthedistancebetweentheanteriorandposteriorcornealsurfaces.Thiscanbecomputedbycalculatingtheperpendiculardistan