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TGF-B3在增生性瘢痕形成不同时期的表达及意义.docx

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TGF-B3在增生性瘢痕形成不同时期的表达及意义 Abstract: Transforminggrowthfactorbeta3(TGF-B3)playsanimportantroleinfibrosisandscarformation.Inthispaper,wediscusstheexpressionandsignificanceofTGF-B3indifferentstagesofhypertrophicscarformation.WeanalyzedtheexpressionofTGF-B3intheinflammatoryphase,proliferationphase,andremodelingphaseofhypertrophicscarformation.WealsoexploredtheroleofTGF-B3inthepathogenesisofhypertrophicscars.Finally,weproposepotentialstrategiestopreventhypertrophicscarformationbasedonthemodulationofTGF-B3expression. Introduction: Hypertrophicscarsareacommoncomplicationofwoundhealing,especiallyinburnpatients.Theyarecharacterizedbytheexcessivesynthesisofextracellularmatrix(ECM)components,includingcollagen,fibronectin,andproteoglycans.Hypertrophicscarscancausesignificantmorbidity,astheycanlimitjointmobilityandcausesevereitchingandpain.Therefore,understandingthepathogenesisofhypertrophicscarsiscrucialfordevelopingeffectivepreventionandtreatmentstrategies. Thedevelopmentofhypertrophicscarscanbedividedintoseveralphases,includingtheinflammatoryphase,proliferationphase,andremodelingphase.Duringtheinflammatoryphase,thewoundisinfiltratedbyinflammatorycells,includingmacrophages,neutrophils,andlymphocytes.ThesecellsreleasecytokinesandgrowthfactorsthatstimulatetheproliferationoffibroblastsandthesynthesisofECMcomponents.Duringtheproliferationphase,fibroblastsmigrateintothewoundandproliferate,producinglargeramountsofECMcomponents.Duringtheremodelingphase,theECMisremodeledandreorganizedtorestoretissuestrengthandfunction. Transforminggrowthfactorbeta(TGF-B)isafamilyofcytokinesthatplaysacriticalroleinthedevelopmentofhypertrophicscars.TGF-B1andTGF-B2havebeenshowntobeinvolvedinthepathogenesisofhypertrophicscars.However,theroleofTGF-B3inhypertrophicscarformationislesswellknown. ExpressionandsignificanceofTGF-B3indifferentstagesofhypertrophicscarformation: TheexpressionofTGF-B3inhypertrophicscarswasanalyzedbyseveralstudies.Overall,theexpressionofTGF-B3wasfoundtobedecreasedinhypertrophicscarsco