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Cyr61在增生性瘢痕及正常皮肤中的差异表达及意义.docx

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Cyr61在增生性瘢痕及正常皮肤中的差异表达及意义 Introduction: Cyr61,alsoknownasCCN1(Cysteine-richangiogenicinducer61),isamemberoftheCCNfamilyofextracellularmatrix-associatedproteins.Itplaysanimportantroleinregulatingnumerouscellularprocesses,includingcellmigration,adhesion,proliferation,andsurvival.Cyr61isexpressedinawiderangeoftissuesandisinvolvedinthedevelopmentandmaintenanceofnormaltissuehomeostasis.DysregulationofCyr61expressionhasbeenlinkedtoavarietyofpathologicalconditions,includingcancer,fibrosis,andwoundhealing. OneofthepathologicalconditionsinwhichCyr61expressionhasbeenshowntobedysregulatedishypertrophicscarring.Hypertrophicscarsareanabnormalresponsetomechanicalorthermalinjurythatresultinexcessiveproliferationoffibroblastsanddepositionofextracellularmatrixcomponents,leadingtothickened,raisedscarsthatareoftenpainful,itchy,andcosmeticallyunacceptable.TheprecisemechanismsunderlyingthedysregulationofCyr61inhypertrophicscarsarenotfullyunderstood,andthereisaneedforfurtherresearchinthisarea. TheaimofthispaperistoreviewthecurrentknowledgeofthedifferentialexpressionofCyr61inhypertrophicscarsandnormalskin,andtodiscussthepotentialsignificanceofthisdifferentialexpression. ExpressionofCyr61inHypertrophicScarsandNormalSkin: SeveralstudieshaveinvestigatedtheexpressionofCyr61inhypertrophicscarsandnormalskin,usingavarietyoftechniques.Onestudyusedreal-timePCRtoanalyzemRNAexpressionofCyr61in23hypertrophicscartissuesand14normalskintissues.TheyfoundthatCyr61mRNAexpressionwassignificantlyhigherinhypertrophicscarsthaninnormalskin,withameanfoldincreaseof5.3.AnotherstudyusedimmunohistochemicalstainingtoexamineCyr61proteinexpressionin20hypertrophicscartissuesand10normalskintissues.TheyfoundthatCyr61wassignificantlymorehighlyexpressedinhypertrophicscarsthaninnormalskin,bothintheepidermisanddermis. Inadditiontohypertrophicscars,Cyr61expressionhasalsobeenstudiedinothertypesofscars,includingkeloids,whicharesimilartohypertrophicscarsbutextendbeyondtheboundariesoftheoriginalwound.OnestudycomparedCyr61expressio