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基于分子内电荷转移的新型Cr（Ⅲ）比率荧光探针（英文）.docx

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基于分子内电荷转移的新型Cr（Ⅲ）比率荧光探针（英文） Abstract AnovelCr(III)ratiofluorescentprobebasedonintramolecularchargetransferwasdesignedandsynthesized.TheprobeexhibitedhighsensitivityandselectivitytowardsCr(III)inthepresenceofcompetingions.Themechanismofprobe-Cr(III)interactionwasinvestigated,andtheresultsdemonstratedthattheprobeunderwentdeprotonationandintramolecularchargetransferuponbindingwithCr(III).TheprobedisplayedasignificantfluorescenceintensityratiochangeuponbindingwithCr(III),enablingitsuseasaratiometricfluorescentprobeforCr(III)detection.TheprobewassuccessfullyappliedforthedeterminationofCr(III)inwatersamples,showinggreatpotentialforpracticalapplications. Introduction Chromiumisatoxicheavymetalwidelyspreadintheenvironmentthatcancauseserioushealthconsequencestohumansandanimals(Chenetal.2014).Cr(III)isanessentialelementforhumannutrition,whileCr(VI)isrecognizedasacarcinogenandhasbeenlinkedtolungcancer,gastrointestinal,andotherhealthproblems(JomovaandValko2011).Therefore,thereisaneedtodevelophighlysensitiveandselectivemethodsforthedetectionofCr(III)inenvironmentalandbiologicalsystems. Fluorescenceprobeshavereceivedincreasingattentionfortheirhighsensitivityandselectivityformetaliondetection(Xuetal.2021).Amongvariousfluorescenceprobes,ratiometricprobesareparticularlyattractivebecausetheycaneliminateinterferencesfromenvironmentalfactors,includingphotobleachingandbackgroundfluorescence(Zhangetal.2020).Therefore,ratiometricfluorescentprobesarepromisingcandidatesforthedetectionofCr(III). Recently,intramolecularchargetransfer(ICT)hasbeenusedtodesignandsynthesizeratiometricfluorescentprobesformetalionsdetection(Liuetal.2020).TheICTprocesscancauseachangeinthefluorescenceintensityratiooftheprobe,enablingittobeusedasaratiometricfluorescentprobeformetalionsensing. Here,wereportanovelCr(III)ratiofluorescentprobebasedonICT,whichdemonstratedhighsensitivityandselectivitytowardsCr(III)inthepresenceofcompetingions.Themechanismofprobe-Cr(III)interactionwasinvestigated,andtheprobewassuccessfullyap