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miRNA29b在增生性瘢痕和正常皮肤组织中表达的比较研究.docx

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miRNA29b在增生性瘢痕和正常皮肤组织中表达的比较研究 Introduction Hypertrophicscarsandkeloidsaretypesofexcessivescarringthatoccuraftercutaneousinjury,surgery,orinflammation.Hypertrophicscarsarecharacterizedbyanovergrowthofconnectivetissuethatremainswithintheconfinesoftheoriginalwound,andkeloidsareatypeofhypertrophicscarringthatexpandsbeyondtheoriginalwoundsiteandinvadesadjacenthealthytissue(1).Theseconditionscanhavesignificantpsychologicalandsocialimpactsonpatientsandaredifficulttotreat.Althoughtheexactmechanismsunderlyingscarformationarenotwellunderstood,researchhasindicatedthatmicroRNAsmayplayaroleinregulatingtheprocess. miRNA29bisamemberofthemiR-29family,whichconsistsofmiR-29a,miR-29b,andmiR-29c.ThisfamilyofmicroRNAshasbeenfoundtobeinvolvedinmanybiologicalprocesses,includingtheregulationofextracellularmatrix(ECM)remodeling.TheECMisacomplexnetworkofmacromoleculesthatprovidesstructuralsupportforcellsandtissuesandplaysacrucialroleintissuehomeostasis.Intheskin,theECMiscomposedmainlyofcollagen,elastin,andglycosaminoglycans.ECMremodelingisessentialforwoundhealing,asitallowsforthedepositionandorganizationofnewcollagen,whichhelpstorestoretissueintegrity.However,aberrantECMremodelingcanleadtoexcessivescarformation. MiRNA29bhasbeenimplicatedintheregulationofECMremodelinginvarioustissues,includingtheskin.StudieshaveshownthatmiRNA29bexpressionisdownregulatedinkeloidandhypertrophicscartissuecomparedtonormalskin,suggestingthatthismicroRNAmayplayaroleinscarformation.TheaimofthisreviewistocomparetheexpressionofmiRNA29binhypertrophicscarsandnormalskintissueandtodiscussitspotentialroleinscarformation. ExpressionofmiRNA29binhypertrophicscarsandnormalskintissue SeveralstudieshaveinvestigatedtheexpressionofmiRNA29binhypertrophicscarsandnormalskintissue.Zhangetal.(2)foundthatmiRNA29bexpressionwassignificantlylowerinhypertrophicscartissuecomparedtonormalskintissue.Similarly,Wuetal.(3)reportedthatmiRNA29bexpressionwasdownregulatedinkeloidtissuecomparedtonormalskintissue.ThesefindingssuggestthatmiRNA29bmaybein