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青岛地区汉族人群KLF14基因多态性与冠心病的相关性研究的任务书.docx

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青岛地区汉族人群KLF14基因多态性与冠心病的相关性研究的任务书 任务书 一、研究背景 Coronaryheartdisease(CHD)isamajorcardiovasculardiseasethathasbecomealeadingcauseofmorbidityandmortalityworldwide.CHDisamultifactorialdiseasethatisinfluencedbygeneticandenvironmentalfactors.AmongthegeneticfactorsthatcontributetotheriskofCHD,singlenucleotidepolymorphisms(SNPs)intheKLF14genehavebeenidentifiedaspotentialriskfactorsforthedevelopmentofCHD.KLF14isatranscriptionfactorthatisinvolvedintheregulationofadiposetissueandinsulinsensitivity.SNPsinKLF14havebeenlinkedtotheriskofCHDinseveralpopulations.However,theassociationbetweenKLF14genepolymorphismsandtheriskofCHDintheHanChinesepopulationinQingdaoremainsunclear.Therefore,thepresentstudyaimstoinvestigatetheassociationbetweenKLF14genepolymorphismsandtheriskofCHDintheHanChinesepopulationinQingdao. 二、研究目的 ThemainobjectiveofthisstudyistoinvestigatetheassociationbetweenKLF14genepolymorphismsandtheriskofCHDintheHanChinesepopulationinQingdao.Specifically,weaimto: 1.DeterminetheprevalenceofKLF14genepolymorphismsintheHanChinesepopulationinQingdao. 2.InvestigatetheassociationbetweenKLF14genepolymorphismsandtheriskofCHDintheHanChinesepopulationinQingdao. 3.EvaluatethecontributionofKLF14genepolymorphismstotheoverallriskofCHDintheHanChinesepopulationinQingdao. 4.ExplorethepotentialmechanismsunderlyingtheassociationbetweenKLF14genepolymorphismsandtheriskofCHDintheHanChinesepopulationinQingdao. 三、研究方法 1.Studydesign:Thiswillbeacase-controlstudythatwillenrollHanChineseindividualsinQingdao.ThestudywillcomparetheprevalenceofKLF14genepolymorphismsinindividualswithCHDwiththosewithoutCHD. 2.Studyparticipants:Atotalof500individualswillbeenrolledinthestudy,including250individualswithCHDand250individualswithoutCHD.TheparticipantswillbeselectedfromthreemajorhospitalsinQingdao.Theinclusioncriteriafortheparticipantswillbe: a.Agebetween40and70years. b.HanChineseethnicity. c.PermanentresidentsinQingdao. d.Informedconsenttoparticipateinthestudy. 3.Datacollection:Thedatacollectionwillinvolveobtainingdeta