n-3多不饱和脂肪酸、内质网应激与非酒精性脂肪肝病的研究进展.pdf

第4卷第4期食品安全质量检测学报Vol.4No.4
2013年8月JournalofFoodSafetyandQualityAug.,2013

n-3多不饱和脂肪酸、内质网应激与非酒精性
脂肪肝病的研究进展

袁发浒,赵秀举,刘志国*

(武汉轻工大学,武汉430023)

摘要:非酒精性脂肪性肝病(nonalcoholicfattyliverdisease,NAFLD)已逐渐成为一个全球性健康问题,但其
发病的具体机制不甚明朗。内质网是细胞内蛋白质加工、脂质合成和钙储存的主要场所,内质网结构和功能的
失常所致的内质网应激(endoplasmicreticulumstress,ERS)对脂代谢和细胞功能具有重要调控作用,可能是
NAFLD的发生和发展的重要机制。近来大量研究显示,脂类中特定的脂质负荷(饱和脂肪酸、胆固醇)可能是
诱导ERS导致NAFLD重要原因,而另一方面,n-3多不饱和脂肪酸(n-3polyunsaturatedfattyacids,n-3PUFA)
的摄入量却与NAFLD患病率呈负相关。本文就脂肪酸与内质网应激及其与NAFLD的联系作一综述,进一步
探讨n-3多不饱和脂肪酸防治NAFLD的机制。
关键词:n-3多不饱和脂肪酸;脂代谢;内质网应激;非酒精性脂肪肝病

Researchprogressoffattyacidsandtheendoplasmicreticulumstress
innon-alcoholicfattyliverdisease

YUANFa-Hu,ZHAOXiu-Ju,LIUZhi-Guo*

(CollegeofBiologyandPharmaceuticalEngineering,WuhanPolytechnicUniversity,Wuhan430023,China)

ABSTRACT:Non-alcoholicfattyliverdisease(NAFLD)isaworldwidepublichealthproblem.Theunderly-
ingcausesofNAFLDareunclear.Endoplasmicreticulumisthemainsiteofproteinprocessing,lipidsynthe-
sisandstorageofcalcium.DisruptionofEndoplasmicreticulumhomeostasis,whichofteninducesendoplasmic
reticulumstress(ERS),playsanimportantregulatoryroleinlipidmetabolismandcellfunction.Recentevi-
denceimplicatedtheERSinboththedevelopmentofsteatosisandprogressiontononalcoholicsteatohepatitis.
Inthecurrentreview,wediscussedtheinvolvementofdifferentfattyacidsinthepathogenesisofNAFLDwith
particularemphasisontheroleofERS,exploredthemechanismofn-3polyunsaturatedfattyacidsinthepre-
ventionandtreatmentofNAFLD.
KEYWORDS:n-3polyunsaturatedfattyacids;lipidmetabolism;endoplasmicreticulumstress(ERS);non-alcoholic
fattyliverdisease(NAFLD)

基金项目:国家自然科学基金(31271855)、湖北省教育厅重点计划项目(D20121808)、湖北省自然科学基金(2012FFB04802)
Fund:SupportedbytheNationalNaturalScienceFoundationofChina(31271855),EducationalCommissionofHubeiProvinceofChina
(D20121808)andNaturalScienceFoundationofHubeiProvinceofChina(2012FFB04802)
*通讯作者:刘志国,教授,主要从事生物技术与食品安全研究。E-mail:[e-mail]
*Correspondingauthor:LIUZhi-Guo,Professor,CollegeofBiologyandPharmaceuticalEngineering