预览加载中，请您耐心等待几秒...

曲克芦丁对STZ糖尿病大鼠认知功能障碍及Nrf2表达的影响的综述报告.docx

预览
1/2
2/2

在线预览结束，喜欢就下载吧，查找使用更方便

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

曲克芦丁对STZ糖尿病大鼠认知功能障碍及Nrf2表达的影响的综述报告 Introduction Diabetesmellitus(DM)isachronicmetabolicdisordercharacterizedbyhighlevelsofglucoseintheblood,whichresultsfromeithertheinabilityofinsulintoregulatebloodsugarlevelsorthereducedproductionofinsulinbythepancreas.Itisregardedasthemostwidespreadandseriousmetabolicdiseaseaffectinghumansworldwide,anditisrecognizedasamajorcardiovascularriskfactor.Inaddition,itisknowntobeassociatedwithcognitivedysfunctionandmemoryimpairment(Takedaetal.,2014).Quercetin(Qu)isaflavonoidthatisfoundinhighquantitiesinfruitsandvegetables,andithasbeendemonstratedtohavevarioushealthbenefits,includingantioxidant,anti-inflammatory,andneuroprotectiveproperties.Inthisreview,wediscussthepotentialeffectsofquercetinonthecognitivefunctionandNrf2expressioninstreptozotocin(STZ)-induceddiabeticrats. EffectsofDMoncognitivefunction StudieshaveshownthatDMhasadetrimentaleffectoncognitivefunction,leadingtomemoryimpairment,learningdeficits,andexecutivedysfunction.Theunderlyingmechanismsforthesecognitivedeficitsremainunclear,buttheyarethoughttoberelatedtooxidativestress,inflammation,andinsulinresistance,aswellasalterationsintheneuralstructureandfunctionofthehippocampus(Hernandezetal.,2019).InSTZ-induceddiabeticrats,cognitivedeclineoccursduetotheincreaseinoxidativestressandthereductionintheantioxidativedefensesystem,whichleadstodamageinthehippocampalneurons.Further,chronichyperglycemiaandinsulinresistanceaffecttheinsulin-signalingpathway,whichisimportantforcognitivefunctionandmemoryconsolidation. Effectsofquercetinoncognitivefunction Quercetinhasbeenshowntohaveantioxidative,anti-inflammatory,andneuroprotectivepropertiesthatcanimprovecognitivefunctionandpreventmemoryimpairment.Quercetincanscavengereactiveoxygenspecies(ROS),reduceoxidativestress,andincreasetheactivityofantioxidantenzymes,improvingtheantioxidantdefensesystem.Additionally,itinhibitstheproductionofpro-inflammatorycytokines,suchasinterleukin-6(IL-6),tumornecrosisfactor-alpha(TNF-α),andinterleukin-1beta(IL-1β),whic