康复新液联合埃索美拉唑治疗消化性溃疡.doc

康复新液联合埃索美拉唑治疗幽门螺杆菌
相关性消化性溃疡临床观察
易文全=1\*GB3①戴志毅
眉山市人民医院消化内科（620010）
【摘要】目的：观察康复新液联合埃索美拉唑、阿莫西林、甲硝唑三联疗法治疗幽门螺杆茵(Helicobacterpylori，HP)相关性消化性溃疡(PepticUlcer，PU)的疗效。方法：将经胃镜检查和C14尿素氮呼气试验确诊的125例幽门螺杆茵(HP)感染相关的消化性溃疡(PU)，随机分两组，=1\*GB3①对照纽：60例，埃索美拉唑40mgqd+阿莫西林1.0bid+甲硝唑0.4bid，三联治疗1周后停抗生素，续用埃索美拉唑40mgqd治疗3周，总疗程4周。=2\*GB3②治疗组：65例，在对照组基础上加用康复新液（攀西制药）10ml，tid，共4周。疗程结束后复查胃镜和HP。比较治疗前后的临床症状评分．溃疡愈合率、HP清除率及1年溃疡复发率。结果：两组治疗后临床症状评分明显低于治疗前（P<0.01），且治疗组症状积分低于对照组（P<0.05）；治疗组溃疡愈合率高于对照组（P<0.05）、1年溃疡复发率低于对照组（P<0.05），两组HP清除率无明显差异(P>0.05)。结论：康复新液有助于改善HP相关性消化性溃疡的临床症状，促进溃疡愈合,减少溃疡复发。
【关键词】康复新液；埃索美拉唑；幽门螺杆菌；消化性溃疡；治疗。

ReportofKangfuxinLiquidinCombinationwithEsomeprazoleTherapyforPepticUlcerofHelicobacterPyloriInfection
Yi-wenquan,Dai-zhiyi
(DepartmentofDigestion,ThePeopleHospitalofMeishan,Sichuan,China,620010)
【Abstract】ObjectiveToobservetheeffectofKangfuxinliquidincombinationwithtripletherapywithEsomelazole，AmoxicillinandMetronidazoleonpepticulcer(PU)ofhelicobacterpylori(HP)infection.MethodsAtotalof125patientswithHP-associatedpepticulcerdiagnosedbygastroscopyandC14ureanitrogenbreathtestwererandomlydividedintotwogroups:controlgrouptreatedwithEsomelazole40mgqd,amoxicillin1000mgbidandmetronidazole400mgbidfor1week,andthentreatedwithEsomelazole40mgqdfor3weeks(n=60);treatmentgroupweretreatedassameasthecontrolgroupandaddedwithKangfuxinliquid10mltidfor4weeks(n=65).Gastroscopyandbreathtestwererepeatedafterthetherapy.Clinicalsymptomscorebeforeandaftertherapy,ulcerhealingrate,HPclearancerateandulcerrelapserateinoneyearwerecomparedwithintwogroups.ResultsClinicalsymptomscoreaftertherapywereobviouslylowerthanscorebeforetherapyinbothgroup(P<0.01)，andtotalscoreintreatmentgroupwaslowerthancontrolgroup(P<0.05);ulcerhealingrateintreatmentgroupwashigherthancontrolgroup(P<0.05);ulcerrelapserateinoneyearintreatmentgroupwaslowerthancontrolgroup(P<0.05).TherewasnosignificantdifferenceinHPclearancerateinbothgroups(P>0.05).ConclusionKangfuxinliquidtherapyforpepticulcerofHP
=1\*GB3①通讯作者：e-mail:[e-mail]
infectio