左旋氨氯地平与氨氯地平治疗高血压的疗效比较.doc

左旋氨氯地平与氨氯地平治疗高血压的疗效比较
刘军：江苏省国营新洋农场医院
邮编：224314
【摘要】目的:比较左旋氨氯地平与氨氯地平对轻、中度高血压病人的临床疗效和不良反应。方法:在2010年10月-2011年3月期间从我院内科门诊抽取轻、中度高血压病人150例，随机分为“左旋氨氯地平”组（治疗组）和“氨氯地平”组（对照组）各75例，“左旋氨氯地平”组以口服左旋氨氯地平2.5mg/d-1或5mg/d-1，“氨氯地平”组口服氨氯地平5mg/d-1或10mg/d-1，观察4-5周，每周嘱咐病人来院测量一次坐位血压，观察治疗效果和不良反应发生情况。结果:治疗组和对照组的治疗总有效率分别为89.30%和86.67%，两组间治疗效果比较无显著性差异（P＞0.05），每组治疗效果前后比较有显著性差异（P＜0.05）。治疗组和对照组的不良反应发生率分别为6.67%和22.67%，两者比较有显著性差异(P＜0.05),且治疗组的不良反应程度明显更轻微。结论：本文比较左旋氨氯地平与氨氯地平对轻、中度高血压病人的临床疗效和不良反应。2.5mg/d-1左旋氨氯地平与5mg/d-1氨氯地平治疗轻、中度高血压的疗效相似，但左旋氨氯地平的不良反应更少、更轻、发生率低。本文对临床用药有参考意义。
【关键词】左旋氨氯地平、氨氯地平、高血压、不良反应

Amlodipinetreatmentwithamlodipinehypertensioncurativeeffectcomparison
LiuJun:JiangsustateXinYangfarmhospital
Zipcode:224314
[Abstract]Objective:comparisonofamlodipineandamlodipineonmildmoderatehypertensionpatients,clinicalefficacyandadversereaction.Methods:in2010October-2011Marchinourhospitalandoutpatientextractionlight,moderatehypertensionpatients:150cases,dividedinto"Levamlodipine"group(treatmentgroup)and"amlodipine"group(controlgroup)ofeachofthe75cases,"Levamlodipine"grouptoorallevorotatoryammoniachloridein2.5mg/D-1or5mg/D-1,"amlodipine"grouporalamlodipine5mg/D-1or10mg/D-1,4-5weekobservation,weeklychargepatientsmeasuredoncesittingbloodpressure,toobservethetherapeuticeffectandadversereactioncases.Results:thetreatmentgroupandthecontrolgrouptreatedwithtotaleffectiveratewere89.30%and86.67%,tocomparethetreatmenteffectbetweenthetwogroupshadnosignificantdifference(P>0.05),eachgroupoftreatmenteffectsandhadsignificantdifference(P<0.05).ThetreatmentgroupandthecontrolgrouptheincidenceofADRwere6.67%and22.67%,bothwithsignificantdifference(P<0.05),andthetreatmentgroupshowedsignificantlymoremildadversereactions.Conclusion:comparedwithamlodipineandamlodipineonmildmoderatehypertensionpatients,clinicalefficacyandadversereaction.2.5mg/D-1L-amlodipineand5mg/D-1amlodipinetreatmentofmild,moderatehypertensionefficacysimilarto,butoflevoamlodipinelessadversereactions,lighterweight,lowerincidenceof.Thispaperhasthereference