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MethodsforthePreparationandManufactureofPolymericNanoparticles.pdf

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PharmaceuticalResearch,Vol.26,No.5,May2009(#2008) DOI:10.1007/s11095-008-9800-3 ExpertReview MethodsforthePreparationandManufactureofPolymericNanoparticles ChristineVauthier1,2andKawtharBouchemal1 ReceivedSeptember17,2008;acceptedDecember1,2008;publishedonlineDecember24,2008 Abstract.Thisreviewsummarizesthedifferentmethodsofpreparationofpolymernanoparticles includingnanospheresandnanocapsules.Thefirstpartsummarizesthebasicprincipleofeachmethodof nanoparticlepreparation.Itpresentsthemostrecentinnovationsandprogressesobtainedoverthelast decadeandwhichwerenotincludedinpreviousreviewsonthesubject.Strategiesfortheobtainingof nanoparticleswithcontrolledinvivofatearedescribedinthesecondpartofthereview.Aparagraph summarizingscalingupofnanoparticleproductionandpresentingcorrespondingpilotset-upis consideredinthethirdpartofthereview.Treatmentsofnanoparticles,appliedafterthesynthesis,are describedinthenextpartincludingpurification,sterilization,lyophilizationandconcentration.Finally, methodstoobtainlabellednanoparticlesforinvitroandinvivoinvestigationsaredescribedinthelast partofthisreview. KEYWORDS:gel;nanocapsules;nanospheres;polyelectrolytecomplex;polymerization;precipitation; purification;scale-up. INTRODUCTIONotherpartofthereviewpresentspostsynthesistreatments thatareappliedtopackagenanoparticlesasamedicine.For Today,polymernanotechnologiesareanimportantpartinstance,thisincludespurification,sterilization,lyophilization ofthemorepromisingfuturetoachievedrugdeliveryandconcentrationmethods.Finally,thelastpartofthereview challengessuchasthosebasedondrugtargetingandonthedescribeshowthenanoparticlescanbelabelledtobecome deliveryofundeliverablemoleculessuchasoligonucleotidesdetectableduringinvitroandinvivoevaluationexperiments. orRNAinterferingeffectors(1–7).Methodsfortheprepa-Thethreelastpartsincludenewsubjectsthatwerenever rationofnanoparticlesareanimportantpartifthischallenge.reviewedbeforeandcomposethemostoriginalpartofthis Theyallowtomakepolymernanoparticleswithsuitable