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BiochemistryChapter11NucleotidesandNucleicacids核苷酸和核酸Informationtransferinacell细胞中信息的转化DNAistransformingmaterial(DNA是转化物质)OTAverytestifiedthetransformingsubstancewasDNA(1944) 证明转化物质是DNAAHersheyandMChasefurthertestifiedtransformingsubstancewasDNAbyinfectionofbacteriawithT2(1952) 进一步通过噬菌体T2对细菌感染的试验证明转化物质是DNAQuestion: Pleasepointoutthebiomolecules thatarerelatedtotheinformationflow.请指出与信息流相关的生物分子mRNAThebases,nucleosideandNucleotide(碱基、核苷、核苷酸)TwotypesofbasesinnucleicacidsTwotypesofsugarsinnucleicacidsStructureofarepresentativenucleotide 代表性核苷酸结构Namesofcommonbases,nucleosidesandnucleotides常见碱基,核苷和核苷酸ADP(adenosine5’-diphosphate)OtherimportantformsofnucleotidesBasicStructureofnucleicacids核酸基本结构Structureofnucleicacids核酸结构ComparisonofchainstructurebetweenRNAandDNAWrittenformsofNucleicacidsorpolynucleotides核酸或多核苷酸的书写方式Schematicalexpressingmodeofnucleicacids核酸图解表示方式Classesornucleicacids核酸的类型Hydrolysisofnucleicacids核酸水解2’-OHinriboseofRNAissusceptibletonucleo- philicattackon3’-phosphodiester(RNA中核糖2‘-OH在碱性条件下,易于亲核进攻3’-磷酸二酯键)EnzymaticcleavageinpolynucleotidechainsExamplesfor“a”or“b”specificexonucleaseHomeworkpp354-355