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骨髓间充质干细胞向神经元样细胞的分化及其在细胞移植中的应用.pdf

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中国组织工程研究与临床康复，2眷3筋2008—01—15出版 JournalofClinicalRehabilitativel~ssueEngineeringResearchJanuary15，2008Vo1．12，No3 骨髓间充质干细胞向神经元样细胞的分化及其在细胞移植中的应用☆ 王新生’，崔慧先 Diferentiationofmesenchymalstemcellsintoneuronlikecellsandtheapplicationincelltransplantation WangXin-sheng’ ，CuiHui-xian Abstract BACKGR0UND：MesenchymalstemcellsexistinbonemarrowstromaandcandifferentiateintothreeblastodermictypecellsExperimental ． Center,HebeiNorth OBJECTIVE：Inthispaperthelastedprogressinthebiologicalcharacteristicsandthemechanismofinducingthemesenchymal University， stemcellsdifferentiationtoneuron-likecellsand山ecellstransplantationinrecentyearswerereviewed． Zhan【由iakou RETRIEVALSTRATEGY：Acomputer-basedonlinesearchofPUBMEDwasundertakentoidentify山erelevantarticlepublished075O【x】．Hebei betweenl999and2007wi山山ekeywordsof”bonemesenchymalstemcells”inEnglish．Meanwhile．山erelevantarticlespublishedProvince，China： froml999to2007weresearchedinChinaJournalFull-textDatabasewiththesarflekeywordsinChinese．Theliteratureswere‘Departmentof Anatomy，Hebei selectedprimaryandtIlecitationofeacharticlewasIookedup．Inclusivecriteria：articlesrelatedto山epresentdevelopmentofMedicalUniversity， mesenchymalstemcellsand山emechanismofinducing山emesenchymalstemcelldifferentiationtoneura1．1ikecellsandthecellsShijiazhuang transplantationwereincluded．Exclusivecriteria：Obsolescentliteraturesorrepetitivestudieswereexcluded．0500l7．Hebei Province，China LITERATUREEVALUAT10N：Among230collectedarticles，72wereselectedaccordingto山einclusivecriteria．andl58oldor repetitiveoneswereeliminated．Finally，29articleswereanalyzedinvolving山eisolation，culture，identification(8articles)，WangXin—slaeng☆． mechanismanddifferentiation(17articles)andtransplantation(4articles)ofmesenchymalstemcells．Studyingford0ct0眦 DATASYNTHESIS：Atpresent，thecytobiologicalandmolecularmechanismsofmesenchymalstemcellsarestilluncertain．Associateprofessor, becauseoflackingofspecificmarkersofmesenchymalstemcells．andmanyproblemssuchashowtoinducethemesenchymalstemE)【DaiⅡ嘲忸lC慨 HebeiN0