充血性心力衰竭患者甲状腺激素水平及临床意义.pdf

宁夏医学杂志2001年2月第23卷第2期NingxiaMedJ,Feb.2001,Vol23,No.2·96·

文章编号:1001-5949-(2001)02-0069-02·论著·
充血性心力衰竭患者甲状腺激素水平及临床意义

荆文庆,姜清茹,薛朝阳

【摘要】目的探讨充血性心力衰竭(CHF)患者血清甲状腺激素(TH)的变化及临床意义。方法用放射免

疫法测定30例CHF患者及30例健康对照者血清三碘甲状腺原氨酸(T3)、四碘甲状腺素(T4)、促甲状腺激素

(TSH)水平。结果CHF患者血清T3、T4、TSH水平分别为0.8±0.28ng/ml、82.21±14.82ng/ml、5.45±2.

06mIU/L,其中T3、T4水平明显低于对照组(P<0.01,P<0.05);治疗后分别为1.38±0.30ng/ml、95.34±15.

82ng/ml、5.35±3.10mIU/L,T3、T4增高与治疗前比较有显著性差异(P<0.01,P<0.05)。结论CHF患者体

内T3、T4水平下降,且与CHF病情呈负相关,观察TH水平变化对判断CHF患者的病情、疗效及预后有一定临床
意义。
【关键词】心力衰竭,充血性;甲状腺激素
【中图分类号】R541.6+1【文献标识码】A

Levelsofthyroidhormoneanditsclinicalsignificanceinpatientswithcongestiveheartfailure
JINGWen-qing,JIANGQing-ru,XUEZhao-yang(Dept.ofCardiology,Yinchuang1stHosp.,Ningxia750001,China)
【Abstract】ObjectivesInordertodeterminethelevelsofthyroidhormone(TH)anditsclinicalsignificanceinpatientswith

congestiveheartfailure(CHF).MethodsThetriiodothyronine(T3),thyroxine(T4),thyroidstimulatinghormone(TSH)inserumof30

patientswithCHFand30normalContrastsweredetectedbyradioimmunoassay.ResultsTheconcentrationsofT3、T4、TSHwere0.

8±0.28ng/ml,82.21±14.82ng/ml,5.45±2.06mIU/LrespectivelyinCHFpatientsandthelevelsofT3、T4ofpatientwerelower

thanthatofnormalcontrasts(P<0.01,P<0.05respectively);TheconcentrationsofT3,T4,TSHwere1.38±0.30ng/ml,95.34

±15.82ng/ml,5.35±3.10mIU/L,respectivelyinCHFpatientsaftertreatment,thelevelofT3、T4werehigherthanpatientofCHF

werenottreated,therewassignificantdifference(P<0.01,P<0.05,respectively).ConclusionsThelevelsofT3,T4inCHFpa2
tientsisdecreased,themoresevereheartfailure,themoreobviousdecreasedofthehormoneswereobserved.Theseindicatethattheal2
terationsofserumthyroidhormonelevelmaybevaluabletodentifythedeteriorationofheartfunction,theeffectoftreatmentandprog2
nosisinpatientswithcongestiveheartfailure.
【Keywords】Heartfailure,congestive;Thyroidhormone

充血性心力衰竭(CHF)时,随着心排血量降低、腺疾病和其它内科疾病的健康人(包括植物神经功能
心功能减退,可引起一系列神经内分泌变化。甲状腺紊乱者)。
激素(TH)对心肌代谢、心脏收缩功能有重要作用。1.2方法:患者分别在入院后第2天和纠正心衰治
为探讨CHF时TH的变化及意义,我们对30例CHF疗2周后(心功能改善至少I级以上),于清晨空腹采
患者