血府逐瘀口服液对冠心病血瘀证患者.pdf

中西医结合学报2008年11月第6卷第11期JournalofChineseIntegrativeMedicine,November2008,Vol.6,No.11#1129#

OriginalClinicalResearch临床论著

血府逐瘀口服液对冠心病血瘀证患者血液流变学的影响
及其与人类血小板抗原3基因多态性的相关性

薛梅,陈可冀,马晓娟,刘剑刚,蒋跃绒,缪宇,殷惠军
中国中医科学院西苑医院心血管实验室,北京100091

目的:观察血府逐瘀口服液对冠心病血瘀证患者血液流变学的影响,分析其与血小板膜糖蛋白Òb(glyco-
proteinÒb,GPÒb)人类血小板抗原3(humanplateletantigen-3,HPA-3)基因多态性的相关性。
方法:筛选符合入选标准的32例冠心病血瘀证患者,进行血瘀证计分并检测血液流变学,采用TaqMan探针
技术检测GPÒbHPA-3基因多态性,血府逐瘀口服液治疗4周后复查血液流变学并进行血瘀证计分。
结果:血府逐瘀口服液治疗后冠心病血瘀证患者血液流变学得到改善,含有至少一个突变型基因C的患者
治疗前后血液黏度、红细胞变形指数及血瘀证计分与AA型患者比较,差异有统计学意义(P<0.05)。
结论:血府逐瘀口服液能减轻冠心病血瘀证患者的血瘀症状,改善冠心病血瘀证患者的血液流变性,这种改
善作用与GPÒbHPA-3基因多态表型有相关性。
关键词:血府逐瘀口服液;冠心病;血瘀;血液流变学;血小板膜糖蛋白Òb;基因
中图分类号:R541.4;文献标志码:A;文章编号:1672-1977(2008)11-1129-07

XueM,ChenKJ,MaXJ,LiuJG,JiangYR,MiaoY,YinHJ.JChinIntegrMed/ZhongXiYiJieHeXueBao.2008;
6(11):1129-1135.
ReceivedJune18,2008;publishedonlineNovember15,2008.
Freefulltext(PDF)isavailableatwww.jcimjournal.com.
Indexed/abstractedinandfulltextlink-outatPubMed.
ForwardlinkingandreferencelinkingviaCrossRef.
DOI:10.3736/jcim20081106OpenAccess

EffectsofXuefuZhuyuOralLiquidonhemorheologyinpatientswith
blood-stasissyndromeduetocoronarydiseaseandtheirrelationshipwith
humanplateletantigen-3polymorphism

MeiXUE,Ke-jiCHEN,Xiao-juanMA,Jian-gangLIU,Yue-rongJIANG,YuMIAO,Hu-ijunYIN
LaboratoryofCardiovascularDiseases,XiyuanHospital,ChinaAcademyofChineseMedicalSciences,Beijing100091,China

Objective:ToinvestigatetheeffectsofXuefuZhuyuOralLiquid,acompoundtraditionalChineseherbal
medicineforresolvingstagnation,onhemorheologyinthepatientswithblood-stasissyndromeduetocoronary
diseaseandtheirrelationshipwithhumanplateletantigen-3(HPA-3)polymorphismofmembraneglycoprotein
Òb(GPÒb).
Methods:Thirty-twopatientswithblood-stasissyndromeduetocoronarydiseasewereselectedinthisstudy.
Blood-stasissyndromescoringwasperformedandhemorheologicalparametersweremeasuredinallsubjects
beforeandafterXuefuZhuyuQralLiquidtreatment.ThegenotypesofGPÒbHPA-3weredeterminedby
TaqManprobetechnology.
Results:Thehemorheologywasimprovedinthepa