加味四妙汤治疗痛风伴高尿酸血症患者的疗效分析.docx

加味四妙汤治疗痛风伴高尿酸血症患者的疗效分析[摘要]目的：观察分析痛风伴高尿酸血症患者应用加味四妙汤治疗的临床疗效。方法：选择我院2018年7月～2019年6月收治的88例非急性发作期痛风伴高尿酸血症患者作为本次的研究对象，随机将所有患者分为例数相同的两组：研究组和对照组，每组各有患者44例。对照组患者应用别嘌呤醇片治疗，研究组患者应用加味四妙汤治疗，比较两组患者的临床疗效，检测并比较两组患者治疗前后血尿酸、血清ET-1水平。结果：两组患者的临床总有效率之间比较（90.91%VS88.64%），差异无统计学意义（P>0.05）。与治疗前比较，治疗后两组患者的血尿酸以及ET-1水平均明显下降（P＜0.05）；与对照组治疗后比较，研究组治疗后ET-1水平明显降低(P<0.05)。治疗后两组患者血尿酸水平之间比较，差异无统计学意义（P>0.05）。结论：痛风伴高尿酸血症患者应用加味四妙汤治疗的临床效果显著，患者血尿酸水平明显降低，血管内皮损伤得到显著改善，值得在临床上进行广泛的推广使用。[关键词]加味四妙汤；痛风；高尿酸血症；临床疗效；内皮素-1Efficacyanalysisofjiweisimiaodecoctioninthetreatmentofpatientswithgoutandhyperuricemia[abstract]objective:toobserveandanalyzetheclinicaleffectofjiweisimiaodecoctiononpatientswithgoutandhyperuricemia.Methods:88patientswithnon-acutegoutandhyperuricemiaadmittedtoourhospitalfromJuly2018toJune2019wereselectedasthesubjectsofthisstudy.Allpatientswererandomlypidedintotwogroupswiththesamenumberofcases:studygroupandcontrolgroup,with44patientsineachgroup.Patientsinthecontrolgroupweretreatedwithallopurinoltablets,whilethoseinthestudygroupweretreatedwithjiaweisimiaodecoction.Theclinicalefficacyofthetwogroupsofpatientswascompared,andtheserumlevelsofuricacidandserumet-1beforeandaftertreatmentweredetectedandcompared.Results:therewasnosignificantdifferencebetweenthetwogroups(90.91%VS88.64%)inthetotaleffectiverate(P>,0.05).Comparedwithbeforetreatment,serumuricacidandet-1levelsinthetwogroupsweresignificantlydecreasedaftertreatment(P<0.05).Comparedwiththecontrolgroupaftertreatment,thelevelofet-1inthestudygroupsignificantlydecreasedaftertreatment(P<0.05).Therewasnosignificantdifferenceinserumuricacidlevelbetweenthetwogroupsaftertreatment(P>.05).Conclusion:jiweisimiaodecoctionhasasignificantclinicaleffectinthetreatmentofpatientswithgoutandhyperuricemia.Theserumuricacidlevelofthepatientshasbeensignificantlyreduced,andthevascularendothelialinjuryhasbeensignificantlyimproved,whichisworthyofextensivepromotionanduseinclinicalpractice.[keywords]addflavorsimiaosoup;Gout;Hyperuricemia;Clinicalefficacy;Endothelin-1痛风是临床上的一种常见病，是