预览加载中，请您耐心等待几秒...

肿瘤相关巨噬细胞的研究新进展.pdf

预览
1/6
2/6
3/6
4/6
5/6
6/6

在线预览结束，喜欢就下载吧，查找使用更方便

下载提示 文本预览

如果您无法下载资料，请参考说明：

1、部分资料下载需要金币，请确保您的账户上有足够的金币

2、已购买过的文档，再次下载不重复扣费

3、资料包下载后请先用软件解压，在使用对应软件打开

1402010243TNF),2:1),M2TAM2),,,TAM,TAM,,TAM,,,TTAM,!∀[8],TAM[14]2TAM,TAM,,,,,:9(Gal9),,(,TAM,)TAM,,,21Gal9Gal9[9]NKCD8+T13TAMGal9NK,,/NKGal9NK[10],Gal9B16F10,NKGal9,,[15],/22COX2TAM[11],/,,TAM,2pH,(COX2)(BCC),[16]COX2/COX2TAM[12],[17]23IL6TNFIL6Kerjaschki[13],TNF2010243141,IL6,,MIF[18]TAMIL6,IL6VEGFMIFSTAT3IL6[21],,IL6STAT3IL6,MIF(HCC)HT29IL6[19]MIFMIF24MIC11(MIC1),MIF(TGF)PLCHepG2VEGF,,Mitchel[22],MIFERK,MIC1MAPKD1(CyclinD1)[20],Ren[23],,MIFERK,MIC1VEGF,:catenin!1CyclinD1VEGFD1Wnt/13cate;SuPA;ninMIFCyclinD1ErbB2MIC1uPA26,T25MIF(MIF):CuNG,TAM,MIFTT,Th1,MIF,[24],27TAM(NO)MIF,IFN∀MIFNO,NO,,,MIF,[25],HSPgp96,(HSP)TGFbFGFPDGFMIFmRNA,,MIFHSPgp96PE,NOPE,MIF[26]IL10HO,22MIFNO[27]1422010243,3TAMT!∀,[28],,,TAM,!∀[29],(ECM)32TAMAkt2,ECMMMP9,Akt2MMP9,(MMP)ECMAkt2,(NSCLC)(CDPNP)TAM,CD68+/CD163+MGMP,CDPNPCD68+/HLADR+70%TAM,,30%[30],TAMsTAMNPTAM31TAMTAM,[31](33TAMIL)6,,[32],TAM,OS(Overallsurvival)[33],4TAM,,MMP9,,,!∀TAMT2010243143,TAM,,TAMIFNMCS[3536],VEGFIL1IL87,(MMP7)MMP9MMP12,,,,(ECTC)[37],,[38]ECTC,,,Th1IL,ECTC2IFN∀Th2IL4,IL10,ECTC[39],!∀6,,,ECTC,NSCLCTAMTAMIFN∀,TAM[30],,IL8GMWhite[34]cDNA(restrictedC,IL18cDNAarrays),30(),mRNA,,VEGFbFGFIL8COX2,15,#∃,:VEGF,VEGF(MTPPE)GMCSFMCSFIFN∀;(HIF),5,1442010243[6]BruyereF,MelenLL,BiacherS,eta.lNoddinglymphangiogertesia,#∃inathreedimensionalculture8ystem[J]NatMethods,2008,5:;431[7]MantovaniA,AllavenaE,SicaA.TumourassociatedmacrophagesasaprototypictypeIIpolarisedphagocytepopulation:roleinTAM,tumourprogression[J].EurJCancer,2004,40:1660TAM[8]MantovaniA,SicaA,AllavenaP,etalTumorassociatedmacroEriksson[4041]phagesandtherelatedyeloidderivedsuppressorcellsasaparaM1digmofthediversityofmacrophageactivation[J]HumanImmu,nology,2009,70:325[9]MantovaniA,Sica1AMacrophages,innateimmunityandcancer:,balan