药学 柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究.doc

河北北方学院2013级药学本科论文NO.论文题目：柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究二目录PAGE\*MERGEFORMAT0目录中文摘要……………………………………………………1英文摘要……………………………………………………2研究论文……………………………………………………3引言……………………………………………………3材料与方法……………………………………………........4结果………………………………………………........7讨论……………………………………………………8结论…………………………………………………....9参考文献................................................................................10附图………………………………………………........11综述…………………………...………………………12致谢……………………………………………………17个人简历……………………………………………………18中文摘要柴胡疏肝散对四氯化碳所致急性肝损伤保护作用的研究摘要目的：观察柴胡疏肝散（CSGS）对四氯化碳（CCl4）引起的小鼠急性肝损伤的保护作用。方法：将小鼠分为正常组，模型组，给药组，采用四氯化碳建立损伤模型，给药组采用柴胡疏肝散（CSGS）进行给药干预，计算肝脏指数并观察肝组织HE染色结果。结果：与正常组比较，四氯化碳组的肝组织HE染色切片的病理变化说明模型制作成功。与四氯化碳组比较，给药组的肝组织染色切片表明给药组小鼠肝损伤情况减轻。结论：柴胡疏肝散对四氯化碳所致的急性肝损伤有显著的保护作用。关键词:四氯化碳；急性肝损伤；柴胡疏肝散英文摘要STUDYONTHEPROTEEFFECTOFCHAIHUSHUGANSANONACUTELIVERINJURYINDUCEDBYCARBONTETRACHLORIDEyAbstractObjective:StudyofChaihuShuGanSan(CSGS)onacuteliverinjuryinducedbycarbontetrachloride（CCl4）.Methods:Themiceweredividedintofourgroups:normol,model,anddruggroups.Bygivingcarbontetrachloridecausesacuteliverinjurymodelinmice,thedruggroupwaspretratedbyCSGS.Afterthemiceweresacrificed,thehepaticindiceswerecaclulated,histopathologicalchangesoflivertissueslicesstainedbyHEstainingwereobservedunderlightmicroscope.Results:Comparedtonormolgroup,thehistopathologicalchangesoflivertissueslicesstainedbyHEstainingofthecarbontetrachloridegrouphaveshowedthemodelwasmadesuccessfully.Conclusion:ChaihuShuGanSanactonacuteliverinjuryinducedbycarbontetrachloridehavepreventiveandtherapeuticeffectsofobviousdamage.Keywords:Carbontetrachloride;Acuteliverinjury：ChaihuShuGanSan正文柴胡疏肝散对四氯化碳