从药品不良事件谈临床药师对肿瘤患者的用药监护.docx

编号：时间：2021年x月x日书山有路勤为径，学海无涯苦作舟页码：第页共NUMPAGES10页第PAGE\*MERGEFORMAT10页共NUMPAGES\*MERGEFORMAT10页从药品不良事件谈临床药师对肿瘤患者的用药监护蔡和平，王卓*，黄瑾，徐慧欣，杨黎（第二军医大学长海医院药学部，上海200433）【摘要】目的：分析第二军医大学长海医院抗肿瘤药品不良事件(ADE)的发生情况及其规律，寻找临床药师对肿瘤患者用药监护的要点，提高抗肿瘤药物的合理用药水平。方法：2004年～2009年全院上报的108例抗肿瘤ADE病例报告进行分类频数统计和分析评价，提出临床药师用药监护点。结果：发生ADE的病例中男性居多。用药当日发生ADE的比例最高。抗肿瘤药物中ADE发生率排居前三位的分别为：奥沙利铂、甲氨蝶呤与紫杉醇。抗肿瘤药物ADE累及系统器官排居前三位的为：中枢神经系统、消化系统及免疫系统。结论：临床药师应重点关注肿瘤患者用药人群、抗肿瘤药物ADE发生时间及抗肿瘤药物ADE累及的器官及表现。通过加强临床药师对抗肿瘤药物用药过程的观察和监护，减少ADE的发生及其造成的损害，促进合理用药。【关键词】抗肿瘤药物；药品不良事件；用药监护；合理用药Pharmaceuticalcarepointsontumorpatient——discussionfromadversedrugeventsofantineoplasticmedicineCAIHe-ping，WANGZhuo*，HUANGJin，YANGLi(DepartmentofPharmacy，ChanghaiHospital,SecondMilitaryMedicalUniversity,Shanghai200433，China)[ABSTRACT]Objective：Toanalyzethecharacteristicsandtheregularityoftheantineoplasticsdruginducedadversedrugevents(ADE)inChanghaihospitalofSecondMilitaryMedicalUniversity;discussthepharmaceuticalcarepointofclinicalpharmacist,soastoprovidereferenceforclinicalsafeandrationalmedication.Methods：Atotalof108casesofADEreportscollectedbyADEmonitoringcenterinthehospitalin2004to2007wereclassifiedandanalyzedstatistically.Thensummarizethepharmaceuticalcarepointsontumorpatientbyclinicalpharmacist.Results：MaleshowedthehigherproportionsofADEthanfemale.ADEoccuredmostoftenonthefirstday.Intheantineoplasticsmedicines,methopterin,oxaliplatinandpaclitaxetookthetop3offrequency.Nervoussystem,digestivesystemandimmunesystemisthetop3involvedsystem-organ.Conclusion:Clinicalpharmacistshouldpayattentiontothepatientgivenantineoplasticdrug.ADEoccurrencetime,antimetaboliteantineoplasticdrug,andADEinvolvedorganisthekeypointsbeingtakencareof.Moreattentionshouldbepaidbyclinicalpharmacisttotheantineoplasticdrugusag