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RNA结合蛋白与转录后调控.pptx

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RegulatoryfactorsformRNAdecayandtranslationRNAbindingproteins(RBPs)HuRAUF1TTPEffectofARE-BPsonthestabilityandtranslationofARE-containingmRNAsARE-BPsmRNAstabilityProteinexpressionTranslationalefficiencyAbundanceIncreaseDecreaseIncreaseDecreaseUpregulatedDownregulatedAUF1c-myc(42)c-myc(46)GM–CSF(55)c-fos(42,67)c-fos(53)IL-3(55)PTH(56)p21(48)GM–CSF(42)CyclinD1(48)TNF-alpha(42)GM–CSF(53,54)IL-3(55)HuRc-fos(59,63,67)p53(99,137)TNF-alpha(139)p21(69)TNF-alpha(139)MyoD(68)Cox-2(139)CyclinA(70)p21(48,68,69)CyclinB1(70)CyclinA(70)NOSII/iNOS(64)CyclinB1(70)GM–CSF(55)CyclinD1(48)Cox-2(71,173)NOSII/iNOS(64)IL-3(55)GM–CSF(59)VEGF(173)TNF-alpha(65,74,139)p53(99,137)Cox-2(71,139)IL-3(55,66)VEGF(62)Myogenin(68)Hel-N1TNF-alpha(74)NF-M(73)NF-M(73)GLUT1(72)GLUT1(72)GLUT1(72)HuDGAP-43(75–77)GAP-43(75,76)TTPc-fos(90)GM–CSF(81)GM–CSF(18,81,83–85,91)TNF-alpha(80)TNF-alpha(18,81,83–86,89,90)IL-2(82)Cox-2(87)IL-3(88)IL-2(82,90)IL-3(18,66,83,84,88)BRF1TNF-alpha(89,93)GM–CSF(55)IL-3(55,92,93)IL-3(55)TIA-1TNF-alpha(120)TNF-alpha(120)Cox-2(121)Cox-2(121)KSRPc-fos(90,93)NOSII/iNOS(102)NOSII/iNOS(102)TNF-alpha(90,93)IL-2(90,93)c-jun(93)CUG-BP2Cox-2(150)Cox-2(150)Cox-2(150)Nucleolinbcl-2(175)TINObcl-2(176)PAIP2VEGF(177)VEGF(177)Interactionofthefactorsinvolvinginpost-transcriptionalregulationAU-richElements(AREs)mRNAsARE-BPsClassMotifExamplesI1to5个散在AUUUAc-mycAUF1,HuR，Hel-N1，HuC，HuD，AUH，GAPDH，Hsp70c-fosAUF1，HuR，Hel-N1，HuD，KSRP，AUHBeta1-ARAUF1PTHAUF1Interferon-gammaGAPDH，Hsp70MyoDHuRp21AUF1，HuR，HuDCyclinAHuRCyclinB1HuRCyclinD1AUF1，HuRPAI-2HuRNOSII/iNOSHuR，KSRPIIA(AUUU)5AGM–CSFAUF1，HuR，Hel-N1，TTP，BRF1，TIAR，KSRP，AUH，GAPDH，Hsp70，hnRNP-A1，hnRNP-CTNF-alphaAUF1，HuR，TTP，BRF1，TIA-1，TIAR，KSRPIIB(AUUU)4AInterferon-alphahnRNP-A1，hnRNP-A2,hnRNP-A3IIC(A/U)(AUUU)3A(A/U)Cox-2AUF1,HuR,HuD,TTP,TIA-1,TIAR,hnRNP-A1，hnRNP-A2,hnRNP-A3，CUDBP2IL-2AUF1，HuR，HuD，TTP。Hsp70，Hsp110，hnRNP-A1IL-3HuR，BEF1，AUH，Nucleolin，TINObcl-2AUF1，HuR，VEGFHuRHuC，HuD，PAIP2IIINoAUUUA,c-junTIAR，CUGBP1U-richregionGLUT1Hel-N1，hnRNP-A2，hnRNP-Lp53HuR，Id