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Histoneubquitination&deubquitinationThestructureofnucleosomeUbquitinUbiquitination&DeubiquitinationGENES&DEVELOPMENT17:2733–2740.byColdSpringHarborLaboratoryPressHistoneubiquitination除了单泛素化,H2A/H2AX在DNA损伤时可发生K63位多泛素化负责H2A/H2B泛素化与去泛素化酶HistoneubiquitinaseHistonedeubiquitinatingenzyme(DUBs)FunctionofHistoneUbiquitinationRegulationofcellcycleprogression—chromosomesegregationduringmitosisTranscriptionregulationubH2A&silencea.HistoneH2AMonoubiquitinationRepressesTranscriptionbyb.HistoneH2AMonoubiquitinationRepressesTranscriptionbyFig.1.ThediverseactivitiesofH2Bub1.H2BUbiquitinationRequiresEarlyStepsinTranscriptionElongation(Co-Transcription)ModelfortheregulationofchromatindynamicsbyH2Bubiquitinationanddeubiquitinationduringtranscriptionelongation.HistonemodificationscrosstalkFigure7.Thetrans-histonecrosstalkbetweenhistoneH2BubiquitinationandH3K4/K79methylationinbuddingyeast.crosstalkbetweenH2BUbiquitination&H3K4methylation参考文件HistoneUb&Cancer