兰索拉唑和莫沙必利治疗老年胃食管反流病的临床观察.docx

兰索拉唑和莫沙必利治疗老年胃食管反流病的临床观察[摘要]目的:探讨兰索拉唑和莫沙必利联合用药对老年胃食管反流病的疗效。方法:将68例老年胃食管反流病患者随机分为两组治疗组采用兰索拉唑和莫沙必利治疗对照组采用法莫替丁和莫沙必利两组疗程为均6周观察症状改善情况并复查胃镜。结果:改善临床症状方面治疗组显效19例有效12例无效3例总有效率为91.18%;对照组显效16例有效11例无效7例总有效率为79.41%。内镜检查显示治疗组治愈率为70.59%总有效率为88.24%;对照组治愈率为58.88%总有效率为76.47%。两组以上指标比较均有非常显著性差异(P[关键词]兰索拉唑;莫沙必利;法莫替丁;胃食管反流病[中图分类号]R57[文献标识码]A[文章编号]1673-7210(2009)08(b)-056-02ClinicalobservationofLansoprazoleandMosaprideinthetreatmentofgastroesophagealrefluxdiseaseinelderlypatientsLUBaichunWENChangsi(ZhangmutouHospitalofDongguanCityDongguan523633China)[Abstract]Objective:ToexploretheclinicalobservationofLansoprazoleandMosaprideinthetreatmentofGastroesophagealrefluxdiseaseinelderlypatients.Methods:68casesofGastroesophagealrefluxdiseaseinelderlypatientswererandomlydividedintotwogroupsthetreatmentgroupwastreatedwithLansoprazoleandMosapridethecontrolgroupwasgivenFamotidineandMosapridethetwogroupsweretreatedfor6weekstheefficacywascomparedandreexaminedgastroscopy.Results:Intheaspectsofimprovingclinicalsymptomsinthetreatmentgroup19caseshadmarkedeffect12caseswereeffective3caseshadnoeffectthetotaleffectiveratewas91.18%.Inthecontrolgroup16caseshadmarkedeffect11caseswereeffective7caseshadnoeffectthetotaleffectiveratewas79.41%.Gastroscopyexaminationshowedthatinthetreatmentgrouptheoverallcureratewas70.59%thetotaleffectiveratewas88.24%.Inthecontrolgrouptheoverallcureratewas58.88%thetotaleffectiveratewas76.47%.Thereweresignificantdifferencesintheaboveindexesbetweenthetwogroups(P[Keywords]Lansoprazole;Mosapride;Famotidine;Gastroesophagealrefluxdisease胃食管反流病(GERD)是指胃十二指肠内容物反流入食管对黏膜食管刺激或造成损伤从而引起临床症状如烧心、反酸、胸痛、反食、恶心或食管炎症临床上可以表现为内镜阳性GERD即内镜下具有食管黏膜破损、糜烂、溃疡等形成即反流性食管炎(RE);也可以表现为内镜阴性GERD即内镜下无糜烂性食管炎表现(NERD)。GERD可发生于所有年龄的人以中老年人最常就医男性食管炎的发病率要比女性高1倍GERD的患病率在西方为