瘦素_脂联素与子痫前期_子痫关系的研究.pdf

·128·ChineseMedicalJournalofMetallurgicalIndustry,April2009,Vol126No12

瘦素、脂联素与子痫前期—子痫关系的研究

郭海荣芦胜群刘萍王爱玲

摘要目的:探讨子痫前期(PE)患者血清瘦素、脂联素水平的变化及其意义。方法:选择38例子痫前期孕妇作为研究组,其中子痫前期轻
度患者16例(B组),子痫前期重度患者22例(C组);选择同期分娩的正常孕妇40例作为对照组(A组)。采用放免法检测血清瘦素水平,采用
ELISA法检测血清脂联素水平。同时检测患者尿蛋白、肾功能(BUN、Cr)水平。结果:(1)PE重度组患者血清瘦素水平(29145±7193)ng/ml,最
高;PE轻度组患者血清瘦素水平(16164±5129)ng/ml,居中;对照组血清瘦素水平(10151±3116)ng/ml,最低,三者两两相比,差异有统计学意义
(P<0105)。PE重度组患者血清脂联素水平(1106±0135)mg/L,最低;PE轻度组患者血清脂联素水平(2133±1146)mg/L,居中;对照组脂联素
水平(4121±0196)mg/L,最高,三者两两相比,差异有统计学意义(P<0105)。(2)子痫前期患者血清瘦素和脂联素呈高度负相关(r=201825,P
<0101)。结论:瘦素、脂联素在PE的发病过程中可能起一定的作用,高瘦素血症和低脂联素血症可能与PE的发生、发展有关。
关键词瘦素;脂联素;子痫前期
中图分类号R714124文献标识码A文章编号1005-5495(2009)02-0128-03

Studyoftherelationshipamongleptinandadiponectinandpreeclampsia.GUOHai2rong,LUSheng2qun,LIUPing,etal1Departmentof
gynecology,theThirdAffiliatedHospitalofInnerMongoliaMedicalCollege1Baotou014010
AbstractObjective:Toexploretheroleofeptinandadiponectininthepathogenesisofpreeclampcia1Methods:Choosing38PEpatientsas
researchgroup,including16patientswithmildpreeclapcia(MPE,groupB)and22patientswithseverepreeclapcia(SPE,groupC),choosing40
normalpregnantwomen(NPW)whodeliverinthecorrespondingperiodascontrastgroup(groupA)1Theserumlevelsofleptinweremeasured
usingradioimmunoassay1Theserumlevelsofadiponectinweremeasuredusingtheenzyme2linkedimmunosorbent,urineprotinandkidneyfunction
weremeasuredmeanwhile1Results:(1)Theserumlevelsofleptinandadiponectininthreegroupswereallsignificantlydifferentinstatistics(P<
0105)1TheserumlevelsofleptininwomenwithSPEwasmaximal,thosewithMPEwasmedium,thoseNPWwasminimum;whiletheserumlevels
ofadiponectininwomenwithSPEwasminimum,thosewithMPEwasmedium,thosewithNPWwasmaximal1(2)Therewasahighlynegative
correlationbetweentheserumlevelsofleptinandadiponectininPEpatients(r=-01825,P<0101)1Conclusions:Leptinandadiponectinmaybe
involvedinthepathogenesisofPE,moreover,highserumlevelsofleptinandlowadiponectinareassociatedwiththeoccurrenceandelovementof
thisdisease1
KeyWordsLeptin;Adiponectin;Pre